viewpointIs BALT a major component of the human lung immune system?
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Cited by (131)
Structure, Organization, and Development of the Mucosal Immune System of the Respiratory Tract
2015, Mucosal Immunology: Fourth EditionAdaptive Immunity
2015, Murray and Nadel's Textbook of Respiratory Medicine: Volume 1,2, Sixth EditionBronchus-Associated Lymphoid Tissue (BALT). Structure and function
2010, Advances in ImmunologyCitation Excerpt :Bronchus-associated lymphoid tissue (BALT) is considered by early investigators to be a mucosal secondary lymphoid tissue embedded in the walls of the large airways (Sminia et al., 1989), similar to Peyer's patches in the small intestine. However, it is clear that BALT is not constitutively present in all mammalian species, notably mice and humans (Pabst, 1992; Pabst and Gehrke, 1990), and is induced in response to microbial exposure or other types of pulmonary inflammation (Tshering and Pabst, 2000). These inducible tissues may be more properly referred to as a tertiary or ectopic lymphoid tissue and we have coined the term inducible BALT (iBALT) to describe them (Moyron-Quiroz et al., 2004).
Pulmonary Manifestations of Primary Sjögren's Syndrome
2008, Rheumatic Disease Clinics of North AmericaCitation Excerpt :Subepithelial aggregates of lymphoid tissue in bronchi and bronchioles have been labeled BALT.73 The presence of BALT in normal human lung remains debated, but there is no doubt that this tissue can be induced under certain pathologic conditions, including: chronic lung infections, chronic viral infections, including HIV, and autoimmune conditions including SS.73,74 Proliferation of BALT may result in peribronchial lymphoid hyperplasia, which can cause airway obstruction, one of the more common pulmonary manifestations of SS,34,39,75 or alveolar interstitial LIP.
Manipulation of acute inflammatory lung disease
2008, Mucosal Immunology