Trends in Pharmacological Sciences
Lipoxygenase metabolites of arachidonic acid in neuronal transmembrane signalling
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2023, International Journal of Biological MacromoleculesPathophysiology of the hepoxilins
2015, Biochimica et Biophysica Acta - Molecular and Cell Biology of LipidsCitation Excerpt :RVD is driven by a K+ gradient associated with the outward movement of KCl; hence, hepoxilin A3 may represent an endogenous mediator required for normal homeostasis [28]. It is interesting to note that hepoxilin A3 was earlier shown to activate distinct K+ channels in the marine mollusk, Aplysia californica [120–122] suggesting that the effects of hepoxilin A3 on RVD may indeed result from hepoxilin causing K+ efflux. The studies by McCormick's group are mostly responsible for the concept that hepoxilin A3 may represent an intrinsic mediator of bacterial infection which creates a chemical gradient through which neutrophils are attracted to the site of infection (the apical surface of intestinal epithelial cells) [76,78].
CJ-13610, an orally active inhibitor of 5-lipoxygenase is efficacious in preclinical models of pain
2009, European Journal of PharmacologyDopamine receptor pharmacology
2007, Handbook of Clinical NeurologyCitation Excerpt :The D4‐, but not D3‐, receptor also activates this pathway (Vial and Piomelli, 1995; Nilsson et al., 1999). Arachidonic acid and its lipooxygenase and cyclooxygenase metabolites have numerous effects on cellular function, including feedback regulation of D2‐like signaling and dopamine transport (Piomelli and Greengard, 1990; DiMarzo and Piomelli, 1992; L'hirondel et al., 1995; Zhang and Reith, 1996). The D2‐receptor can also stimulate phospholipase D, catalyzing the hydrolysis of phosphatidylcholine to form choline and phosphatidic acid (Mitchell et al., 1998; Senogles, 2000).
The electro-oculogram
2006, Progress in Retinal and Eye Research