Original articleAirway refractoriness to adenosine 5′-monophosphate after repeated inhalation
References (28)
- et al.
Adenosine inhibits and potentiates IgE-dependent histamine release from human lung mast cells by an A2 purinoceptor-mediated mechanism
Biochem Pharmacol
(1984) - et al.
Adenosine-induced bronchoconstriction in asthma: role of mast cell mediator release
J Allergy Clin Immunol
(1985) - et al.
The relationship between mast cell-mediator release and bronchial reactivity in allergic asthma
J Allergy Clin Immunol
(1987) - et al.
Adenosine-induced bronchoconstriction in asthma: specificity and relationship to airway reactivity
Thorax
(1983) - Cushley MJ, Tattersfield AE, Holgate ST. Adenosine antagonism as an alternative mechanism of action of methylxanthines...
- et al.
Antigen bronchial provocation causes an increase in plasma adenosine levels in asthma
Clin Sci
(1983) - et al.
Adenosine release from stimulated mast cells
- et al.
Release of adenosine and its metabolites from human leukocytes
Clin Sci
(1986) - et al.
Adenosine-induced bronchoconstriction in asthma: antagonism by inhaled theophylline
Am Rev Respir Dis
(1984) - et al.
Effect of vagal blockade on adenosine-induced bronchoconstriction in asthma
Thorax
(1984)
Potentiation of mast cell mediator release by adenosine
J Immunol
Adenosine inhibits and potentiates IgE-dependent histamine release from human basophils by an A2 receptor-mediated mechanism
Br J Pharmacol
Adenosine receptors on mouse bone marrow-derived mast cells—functional significance and regulation by aminophylline
J Immunol
The bronchial effects of adenosine in the rat
Arch Int Pharmacodyn Ther
Cited by (28)
Refractoriness to inhaled mannitol 3 hours after allergen challenge
2013, Annals of Allergy, Asthma and ImmunologyCitation Excerpt :The number of patients was too small to attempt to stratify the population, and we did not capture the LAR; in fact, we inhibited any potential LAR with a single dose of fluticasone. Refractoriness, even cross-refractoriness, is well recognized after indirect challenges.2–6 Early studies documented that airway responsiveness to methacholine5 and histamine20 were preserved at a time when airways were refractory to a repeat indirect challenge.
Refractoriness to Exercise Challenge. A Review of the Mechanisms Old and New.
2013, Immunology and Allergy Clinics of North AmericaCitation Excerpt :The more intense the exercise during the first challenge, the more refractory the patients were to the second challenge. A refractory period occurs not only after exercise challenge but also after other indirect challenges, such as EVH,30,31 hypertonic saline,32 adenosine,33 ultrasonically nebulized distilled water,34 and mannitol.35,36 All these indirect challenges are associated with the release of mediators, all are inhibited by premedication with sodium cromoglycate, and all are thought to induce refractoriness via a similar pathway.37
Application of a shortened inhaled adenosine-5′-monophosphate challenge in young children using the forced oscillation technique
2009, ChestCitation Excerpt :We found the log10 PC values increased significantly with the second AMP challenge compared to the initial challenge, although without altering the categorical designation of responsive or nonresponsive. Refractoriness following AMP challenge testing has been demonstrated18 to last up to 6 h; therefore, it is unlikely to have caused the small increase in PC values seen in the present study in which tests were at least 6 days apart. The increase in PC values did not alter the only clinically significant result, which is the categorical designation of responsive or nonresponsive.
The effect of challenge method on sensitivity and reactivity to adenosine 5′-monophosphate in subjects with suspected asthma
2006, ChestCitation Excerpt :Finally, inhalation challenges were performed randomly and were separated by 1 to 5 days. This is relevant to the evaluation of AMP responsiveness because it has been demonstrated that, at least in atopic nonasthmatic subjects, repeated inhalation challenge with AMP induces a loss of response or refractoriness to the nucleotide.31 However, the time taken for the AMP PC20 values to return to the starting baseline value ranged from 2 to 6 h, and, to our knowledge, tachyphylaxis to AMP has not been seen after 24 h.
Adenosine-induced bronchoconstriction and its inhibition by nedocromil sodium
1993, The Journal of Allergy and Clinical ImmunologyRepeated exposure of asthmatic airways to inhaled adenosine 5′-monophosphate attenuates bronchoconstriction provoked by exercise
1990, The Journal of Allergy and Clinical Immunology