Original articleRelease of leukotrienes in patients with bronchial asthma☆
References (34)
- et al.
A review of recent contributions on biologically active products of arachidonate conversion
Int J Immunopharmacol
(1982) - et al.
Bronchoconstriction produced in man by leukotrienes C and D
Lancet
(1981) - et al.
Effects of leukotrienes C4 and D4 on glycoprotein and lysozyme secretion by human bronchial mucosa
Prostaglandins
(1983) - et al.
Selective generation of leukotriene B4 by tracheal epithelial cells from dogs
Biochem Biophys Res Commun
(1983) Bronchoalveolar lavage and asthma: sampling the humors speeds up [Editorial]
J Allergy Clin Immunol
(1987)- et al.
Effects of theophylline, terbutaline, and prednisone on antigen-induced bronchospasm and mediator release
J Allergy Clin Immunol
(1980) - et al.
Glucocorticoid receptors in normal human eosinophils: comparison with neutrophils
J Allergy Clin Immunol
(1981) - et al.
The effect of an orally active leukotriene antagonist, LY171883, on antigen-induced airway responses in allergic sheep
Prostaglandins
(1986) Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation
Science
(1983)- et al.
Cellular and biochemical events in the pathogenesis of asthma
Eur J Respir Dis [Suppl]
(1986)
Allergen challenge of lung tissue from asthmatics elicits bronchial contraction that correlates with release of leukotrienes C4, D4, and E4
Allergen induced histamine release and immunoreactive leukotriene C4 generation from leukocytes in mite-sensitive asthmatic patients
Prostaglandins
Effect of bronchial lavage volume on cellular and protein recovery
Chest
Studies on the release of leukotrienes and histamine by human lung parenchymal and bronchial fragments upon immunologic and nonimmunologic stimulation
J Exp Med
Immunological and nonimmunological release of leukotrienes and histamine by guinea pig heart
Immunology
Leukotrienes are potent constrictors of human bronchi
Nature
Effects of leukotriene D on the airways in asthma
N Engl J Med
Cited by (216)
Lipid Mediators and Lung Function
2015, Comparative Biology of the Normal Lung: Second EditionAirway smooth muscle in asthma: Linking contraction and mechanotransduction to disease pathogenesis and remodelling
2014, Pulmonary Pharmacology and TherapeuticsCitation Excerpt :Furthermore, in adult subjects with asthma, the presence of ASM tone reduces airway distensibility in vivo [57]. Thus in diseases such as asthma, where the airway may be exposed to sustained levels of contractile mediators [58–61], reduced degradation of ACh [62], and reduced production of the endogenous bronchodilator nitric oxide [63], the ASM may adopt a state of overall increased stiffness. The implications of mechanical remodelling as a consequence of ASM contraction and stiffening may be profound.
Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E<inf>4</inf> ligand
2013, Journal of Biological ChemistryCitation Excerpt :The cys-LTs are mediators of bronchial asthma on the basis of their potent bronchoconstrictive activity via the CysLT1R in pharmacologic studies and the clinical effectiveness of CysLT1R antagonists (5, 6). LTE4, the most abundant cys-LT at sites of inflammation due to its stability (7, 8), was only a weak agonist for the CysLT1R and CysLT2R in studies with transfectants (3, 4), suggesting that it might lack agonist activity. In contrast, pretreatment with LTE4, but not LTC4 or LTD4, enhanced the response of guinea pig trachea (9) or human bronchial smooth muscle to histamine (10).
Mechanisms of intrinsic force in small human airways
2012, Respiratory Physiology and NeurobiologyCitation Excerpt :Of course, in airway diseases such as COPD and asthma enhanced airway luminal narrowing are caused by excessive shortening of ASM. The excessive shortening could result from exposure to spasmogens (Driver et al., 1993; Lam et al., 1988; Mattoli et al., 1991; Murray et al., 1986; Wenzel et al., 1991; White and Eiser, 1983), increased ASM mass (Hogg et al., 2004), increased myocyte contractility (Opazo Saez et al., 2000), reduced load on ASM (Bosse et al., 2007), or length adaptation of myocytes to passively or actively shortened lengths (McParland et al., 2005). However, another property of ASM which could affect nascent airway diameter is the force generation in the absence of concurrent neural or humeral (i.e., spasmogen) stimulation.
Quantitative measurement of cysteinyl leukotrienes and leukotriene B4 in human sputum using ultra high pressure liquid chromatography-tandem mass spectrometry
2011, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life SciencesDesign and synthesis of an all-in-one 3-(1,1-difluoroprop-2-ynyl)-3H-diazirin-3-yl functional group for photo-affinity labeling
2009, Bioorganic and Medicinal Chemistry
- ☆
Supported by the British Columbia Health Care Research Foundation and the British Columbia Lung Association.
- 1
S. Lam, MD, UBC Respiratory Division, Vancouver General Hospital, 2775 Heather St., Vancouver, B.C. V5Z, 3J5, Canada.