Original articleFrequent administration by inhalation of salbutamol and ipratropium bromide in the initial management of severe acute asthma in children
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Cited by (76)
Treatment
2008, Pediatric Respiratory MedicineComparison of nebulized ipratropium bromide with salbutamol vs salbutamol alone in acute asthma exacerbation in children
2006, Annals of Allergy, Asthma and ImmunologyIpratropium bromide plus nebulized albuterol for the treatment of hospitalized children with acute asthma
2001, Journal of PediatricsCitation Excerpt :Separate pooled analyses5,13 of 1064 adults from 3 trials found a reduction in hospitalization rate from combination therapy, but the reported magnitude of this reduction was different for each analysis and was statistically significant in only one. For children treated in the ED setting, most of the trials demonstrate small but significant additional enhancement of lung function,14-17 clinical outcome,7,18 or both6 in at least a subset of subjects randomized to combination therapy. Reliance on peak expiratory flow measurements, small sample size, or exclusion of children with more severe acute obstruction may explain why some trials19-21 failed to detect enhanced bronchodilation from the addition of anticholinergic agents.
Copyright © 1988 Published by Mosby, Inc.