Original article
Metered-dose inhaler usage in subjects with asthma: Comparison of Nebulizer Chronolog and daily diary recordings,☆☆

https://doi.org/10.1016/0091-6749(88)90043-7Get rights and content

Abstract

The Nebulizer Chronolog (NC) is a portable electronic device that attaches to standard metered-dose inhalers (MDIs) and records and stores the date and time of each MDI actuation. We evaluated the long-term performance of the NC and compared its data to concurrent recordings of self-administered MDI usage in daily diaries. Eighty-three subjects with asthma were evaluated during a 712-month panel study of air pollution effects. Although 44 (53%) of the NCs developed a malfunction during the study, the average total (±SD) percentage of useful days with functioning NCs was still 86 ± 18% (median 93%). The agreement between the daily diary and NC recordings was very high, that is, 50 (67%) of 75 subjects had perfect agreement. Eighteen subjects with over or under diary reporting were detected. We conclude that the NC is an effective, objective, accurate, and continuous monitor of daily MDI usage despite some remediable technical problems. The NC can facilitate the evaluation of short- and long-term medication usage patterns and compliance issues in MDI-related research and clinical settings.

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Supported by California Air Resources Board, Sacramento, Calif., Contracts A1-151-33 and A4-135-33.

☆☆

The statements and conclusions in this report are those of the authors and not necessarily those of the California Air Resources Board. The mention of commercial products, their source, or their use in connection with material reported herein is not to be construed as either actual or implied endorsement of such products.

From the Department of Medicine, University of California-Los Angeles School of Medicine.

∗∗

From the Biostatistics Division, University of California—Los Angeles School of Public Health, Los Angeles, Calif.

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