Original articleMaternal smoking influences cord serum IgE and IgD levels and increases the risk for subsequent infant allergy☆
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Cited by (212)
Prevention of food and airway allergy: Consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics
2016, World Allergy Organization JournalCitation Excerpt :Numerous studies have been conducted to evaluate whether exposure to second-hand smoke can increase the risk of allergic sensitisation in a dose-dependent manner, especially with regard to allergens to which the child is exposed from the first months of life (dust mites, cat epithelium, food allergens). One of the first studies of this topic showed that smoking in pregnancy is associated with increased levels of IgE in umbilical cord blood [194]. A multicenter study of 342 German children showed that a correlation existed between passive smoking and sensitisation to food allergens, but not between smoking and sensitisation to aeroallergens [195].
Early-life Exposure to Widespread Environmental Toxicants and Health Risk: A Focus on the Immune and Respiratory Systems
2016, Annals of Global HealthCitation Excerpt :The IgG, IgM, and IgA levels were higher in cord blood serum of children from mothers who smoked during pregnancy.70 Maternal smoking during pregnancy also caused a significant elevation of IgE and IgD levels in cord blood of newborns.71 Maternal smoking after birth caused an increase in total salivary IgA levels, rather than levels of specific IgA to common colonizing bacteria (pneumococcal PS serotype 14 and NTHI OMP6) in infants at 12 months of age.72
Effects of Environmental Tobacco Smoke during Early Life Stages
2014, The Lung: Development, Aging and the Environment: Second EditionCarryover of cigarette smoke effects on hematopoietic cytokines to F1 mouse litters
2011, Molecular ImmunologyCitation Excerpt :Interventions aimed at reducing allergen exposure immediately after birth have largely resulted delayed onset of disease rather than prevention (Hide et al., 1996; Zeiger et al., 1992), suggesting that immunologic memory is established before birth and is retained during the early months of life. Antenatal smoking is thought to increase cord blood IgE levels (Magnusson, 1986), and to increase the prevalence of eczema and IgE levels (Kjellman, 1981). The pace at which such diseases are increasing worldwide has led us to hypothesize that CS-induced respiratory disease is influenced by interactions between multiple genetic factors and may be transmitted from generation to generation.
Parental smoking increases the risk for eczema with sensitization in 4-year-old children
2010, Journal of Allergy and Clinical ImmunologyPerinatal Exposure to Tobacco and Respiratory and Allergy Symptoms in First Years of Life
2009, Archivos de Bronconeumologia
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Supported by Swedish Medical Research Council Grant No. 16X-105.