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The associations of race, cigarette smoking, and smoking cessation to measures of the immune system in middle-aged men

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Abstract

To estimate the association between the immunologic responses of the cell-mediated and humoral systems and race or tobacco smoking, we used data from the Vietnam Experience Study conducted by the Centers for Disease Control. That study, done from 1985 to 1986, was based on a random sample of 4462 male, Vietnam-era, U.S. veterans. Racial groups were white, black, Hispanic, Asian, and American Indian. We used linear regression to evaluate how (i) the race of the subjects, (ii) the number of pack-years of cigarettes the subjects smoked, and (iii) the smoking cessation of certain subjects were associated with their relative and absolute T, B, CD4, and CD8 lymphocyte counts and immunoglobulin A (IgA), IgM, and IgG levels. The results indicated that immune status was associated with race and smoking history and that, generally, the associations remained after adjustment for covariates. For example, the average IgA level and absolute CD8 lymphocyte count for blacks were, respectively, 19 and 16% higher than those for whites. On the other hand, smokers had lower immunoglobulin levels and relative CD8 cell counts and higher counts for other lymphocytes of the cell-mediated system than nonsmokers. For example, the average absolute B count of heavy smokers was 37% higher than that of nonsmokers. The pattern after cigarette smoking cessation was consistent with a reversible effect of smoking and a return toward immune levels of nonsmokers.

References (35)

  • M. Ferson et al.

    Low natural killer-cell activity and immunoglobulin levels associated with smoking in human subjects

    Int. J. Cancer

    (1979)
  • R.C. Burton et al.

    Effects of age, gender, and cigarette smoking on human immunoregulatory T-cell subsets: Establishment of normal ranges and comparison with patients with colorectal cancer and multiple sclerosis

    Diagn. Immunol.

    (1983)
  • Y.C. Smart et al.

    Differential effect of cigarette smoking on recirculating T lymphocyte subsets in pregnant women

    J. Immunol.

    (1986)
  • Y. Aizawa et al.

    Lymphocyte subpopulations and lymphocyte reactivity in chronic cigarette smokers

    Japan. J. Hyg.

    (1987)
  • D.A. Hugues et al.

    Numerical and functional alterations in circulatory lymphocytes in cigarette smokers

    Clin. Exp. Immunol.

    (1985)
  • P. Hersey et al.

    Effects of cigarette smoking on the immune system: Follow-up studies in normal subjects after cessation of smoking

    Med. J. Aust.

    (1983)
  • Centers for Disease Control Vietnam Experience Study

    Health status of Vietnam Veterans. II. Physical health

    JAMA

    (1988)
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    Data for this study were gathered under an interagency agreement with the Veterans Administration. Use of trade names is for identification only and does not constitute endorsement by the Public Health Service or the U.S. Department of Health and Human Services.

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