The pathologic spectrum of the nephropathy associated with α1-antitrypsin deficiency
References (29)
- et al.
Glomerular lesions associated with liver cirrhosis: An immunohistochemical and clinicopathologic analysis
Hum Pathol
(1986) - et al.
Glomerular alterations associated with obstructive jaundice
Hum Pathol
(1987) - et al.
Aggregation of plasma Z type α1-antitrysin suggests basic defect for deficiency
FEBS Lett
(1986) - et al.
The role of α1-antitrypsin deficiency in the pathogenesis of immune disorders
Clin Immunol Immunopathol
(1985) - et al.
Membranoproliferative glomerulonephritis in childhood cirrhosis associated with alpha1-antitrypsin deficiency
Pediatrics
(1976) - et al.
Membranoproliferative glomerulonephritis and α1-antitrypsin deficiency in children
Pediatrics
(1983) - et al.
Juvenile cirrhosis and membranous glomerulonephritis in a child with alpha1-antitrypsin deficiency PiSZ
Acta Pediatr Scand
(1978) - et al.
The polymorphism of prealbumins and α1-antitrypsin in human sera
Clin Chem Acta
(1967) - et al.
Isoelectric focusing in agarose: Classification of genetic variants of alpha-1-antitrypsin
Clin Chem
(1983) - et al.
Monoclonal antibody specific for the mutant antitrypsin and its application in an ELISA procedure for identification of PiZ gene carriers
Proc Natl Acad Sci USA
(1984)
WHO Classification and Atlas of Glomerular Diseases
Glomerular changes in patients with cirrhosis of the liver
Adv Nephrol
Immune complex type glomerulonephritis in cirrhosis of the liver
Am J Pathol
“Cirrhotic glomerulosclerosis,” a renal lesion associated with hepatic cirrhosis
Lab Invest
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Application of directed evolution and back-to-consensus algorithms to human alpha1-antitrypsin leads to diminished anti-protease activity and augmented anti-inflammatory activities
2020, Cellular ImmunologyCitation Excerpt :Clinically, hAAT is mostly associated with its genetic deficiency (AATD), a condition associated with early-onset lung emphysema in smokers and non-smokers, as well as liver cirrhosis [11,12]. However, recent data suggests an increased risk for other comorbidities, such as vasculitis [13], bacterial pneumonia [14], cervical artery dissection [15], type II diabetes mellitus [16], HIV infection [17], glomerulonephritis [18], poor wound healing [19] and even mood disorders [20]. Currently, the sole clinically approved therapy for AATD is the life-long weekly infusion of serum-purified hAAT (sp-hAAT), recently found to slow the progression of pulmonary emphysema [21].
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2015, Diagnostic Pathology: Kidney DiseasesGenetic and metabolic liver disease
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2011, MacSween's Pathology of the Liver: Expert Consult: Online and PrintThe discovery of α1-antitrypsin and its role in health and disease
2011, Respiratory MedicineCitation Excerpt :Several reports have described AATD patients having both liver disease and rheumatoid arthritis100 and larger studies from Canada and Sweden have shown an increased frequency of AATD phenotypes in patients with rheumatoid arthritis compared to population frequencies.101,102 In addition, in the setting of AATD-associated chronic liver disease, renal disease is often seen in children and young adults.103,104 Numerous reports have also associated AATD and pancreatitis, inflammatory bowel disease, celiac disease, peptic ulcer disease, fibromuscular dysplasia, aneurysms and coronary atherosclerosis.
Supported by a contract with the National Institutes of Health (DK 62274), by grants from the National Institutes of Health (AI 10704, DK 07087, and DK 34931), and by a grant from the Viking Children's Fund, I.D.D. is a recipient of the Burroughs Wellcome Fellowship Award, National Kidney Foundation, Inc.