Elsevier

Tubercle

Volume 69, Issue 2, June 1988, Pages 139-143

Original article
Mycobacterium xenopi infection and aspergilloma

https://doi.org/10.1016/0041-3879(88)90077-3Get rights and content

Abstract

In 11 patients with pulmonary disease due to Mycobacterium xenopi, definite aspergilloma subsequently developed in five and probable aspergilloma in a further three. Those patients with evidence of Aspergillus infection formed a much higher proportion (73 %) than in previous reports of patients with mycobacterial disease. Patients with both Mycobacterium xenopi infection and aspergilloma appear to have a poor prognosis.

Résumé

Parmi 11 malades qui présentaient une maladie pulmonaire due àMycobacterium xenopi, 5 ont vu apparaitre ultérieurement un aspergillome certain et trois autres un aspergillome probable. Ces malades, chez lesquels on a trouvé une infection àAspergillus. représentaient une proportion beaucoup plus élevée (73 %) que dans d'autres études précédentes concernant les malades porteurs d'une maladie mycobactérienne.

Les cas où il existe à la fois une infection àMycobacterium xenopi et un aspergillome, semblent avoir un mauvais pronostic.

Resumen

De 11 pacientes con enfermedad pulmonar debida a Mycobacterium xenopi, 5 desarrollaron ulteriormente un aspergiloma bien definido y otros 3 un aspergiloma probable. Estos pacientes, en los cuales se encontró una infección con Asperquillus representaban una proporción mucho más elevada (73 %) que en estudios precedentes de sujetos con enfermedad micobacteriana.

Los enfermos con ambas infecciones. Mycobacterium xenopi y aspergiloma parecen tener mal pronóstico.

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There are more references available in the full text version of this article.

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    A chest radiograph and CT scans for one such patient are shown in Figure 3. Pulmonary mycetomas occur most commonly in preexisting tuberculous cavities, but they have also been described in lungs that have been destroyed by sarcoidosis,16 bronchiectasis,17 lung abscess,17 neoplasms,18 pulmonary infarcts,19 nontuberculous mycobacteria,20 various mycoses,2122 and PCP.1013 HIV-infected patients are at increased risk for several of these conditions (TB, bacterial and fungal infections, and PCP).

  • Pulmonary resection for Mycobacterium xenopi pulmonary infection

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    Therefore, resection seems necessary to obtain reliable cure and prevent relapse in patients with M xenopi pulmonary disease who can tolerate resection, especially those with cavitary disease. Other arguments support early operation in patients with M xenopi pulmonary disease: more than 70% of such patients subsequently develop aspergilloma, a proportion much higher than in other NTM diseases [21]. Moreover, unsuspected lung cancer was diagnosed on surgical specimens in 2 patients in our series operated on with a therapeutic intent [22].

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