Rapid communicationEndogenous nitric oxide counteracts antigen-induced bronchoconstriction
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Cited by (45)
Brain-derived neurotrophic factor enhances histamine-induced airway responses and changes levels of exhaled nitric oxide in guinea pigs in vivo
2008, European Journal of PharmacologyProduction of nitric oxide by airways neutrophils in the initial phase of murine asthma
2007, International ImmunopharmacologyCitation Excerpt :We have recently shown [18] that inhibition of NOS2 by l-NAME reduced airway hyperreactivity and eosinophil infiltration in allergic lung inflammation in mice suggesting that NO has a pro-inflammatory effect. Similar studies in guinea pigs have shown that NOS inhibitors potentiated acute bronchoconstriction induced by allergen inhalation [32,33], whereas other studies in vitro and in vivo showed that the hyperreactivity induced by allergens is not affected by pretreatment with NOS inhibitors [33,34]. These discrepant results could be attributed to the different models employed but also to the phase of the allergic inflammation analyzed.
Acute inhibition of inducible nitric oxide synthase but not its absence suppresses asthma-like responses
2005, European Journal of PharmacologyCitation Excerpt :Actually, the role of nitric oxide in the airway hyperreactivity is controversial (Ricciardolo et al., 1997; Ricciardolo, 2003; Keller et al., 2005). Some studies in guinea pigs have shown NOS inhibitors potentiate acute bronchoconstriction induced by allergen inhalation (Persson et al., 1993; Mehta et al., 1997), whereas other studies in vitro and in vivo showed that the hyperreactivity induced by allergen is not affected by pre-treatment with NOS inhibitors (de Boer et al., 1996; Mehta et al., 1997). In a recent clinical study, NOS2 inhibitors were able to decrease the exhaled nitric oxide levels in asthmatics patients but the benefit of this treatment on clinical symptoms was not reported (Hansel et al., 2003).
Arginase and asthma: Novel insights into nitric oxide homeostasis and airway hyperresponsiveness
2003, Trends in Pharmacological SciencesNitric oxide in respiratory diseases
2002, Pharmacology and TherapeuticsMeasurement of exhaled nitric oxide in humans and animals
1999, Pulmonary Pharmacology and Therapeutics