Antagonism of arachidonic acid-induced bronchoconstriction in cats by aspirin-like analgesics

https://doi.org/10.1016/0014-2999(76)90072-8Get rights and content

Abstract

In cats, anesthetized with chloralose, vagotomized and relaxed by infusion of suxamethonium, bronchoconstrictor reactions were induced by the i.v. injection of arachidonic acid (50 to 200 μg/kg). These reactions could be completely suppressed by the following drugs: indomethacin (ED50 0.16 mg/kg), flufenamic acid (1.8 mg/kg), acetylsalicyclic acid (2.4 mg/kg) and phenylbutazone (4.7 mg/kg), but paracetamol was only partly effective even in doses up to 50 mg/kg. The results show that rather small doses of most weak analgesics can effectively inhibit prostaglandin biosynthesis in the bronchi and make it likely that this inhibition is involved in the drug-induced bronchoconstrictor reactions, which have been observed clinically.

References (12)

  • R.J. Flower et al.

    Inhibition of prostaglandin biosynthesis

    Biochem. Pharmacol.

    (1974)
  • H.-H. Frey et al.

    On the effect of prostaglandins E2 and F2α on bronchial tonus in cats

    European J. Pharmacol

    (1974)
  • J.J. Burns et al.

    The physiological disposition of phenylbutazone (Butazolidin) in man and a method for its estimation in biological material

    J. Pharmacol. Exptl. Therap.

    (1953)
  • D.C. Delaney et al.

    Prostaglandin levels in blood plasma during asthmatic attacks in patients with aspirin idiosyncrasy

    Postgrad. Med. J.

    (1975)
  • J. Epton et al.
  • R.J. Flower

    Drugs which inhibit prostaglandin biosynthesis

    Pharmacol. Rev.

    (1974)
There are more references available in the full text version of this article.

Cited by (2)

  • Bronchoactive metabolites of arachidonic acid and their role in airway function

    1981, Prostaglandins

  • Effects of inhibitors of thromboxane synthesis on reactions of the cat bronchus in situ to prostaglandins

    1980, Prostaglandins
View full text
Copyright © 1976 Published by Elsevier B.V.