Scientific paperUse of purified streptokinase in empyema and hemothorax☆,☆☆
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Cited by (86)
Pleural Infection
2021, Encyclopedia of Respiratory Medicine, Second EditionHemothorax: Etiology, Diagnosis, and Management
2013, Thoracic Surgery ClinicsCitation Excerpt :The utility of this modality for retained hemothorax in trauma patients is less evident. Multiple studies in trauma patients have demonstrated that fibrinolytic therapy can result in effective drainage of the pleural space.16–19 However, analysis of these results are plagued by small sample sizes, lack of controls, and difficulty in quantifying resolution of hemothorax.16
Intrapleural fibrinolytic therapy for pleural infection
2007, Pulmonary Pharmacology and TherapeuticsCitation Excerpt :Side effects from impurities dampened enthusiasm, but more purified streptokinase and the availability of urokinase led to reappraisal of this fibrinolytic therapy [16,17,20,21]. Streptokinase is a non-enzymatic protein produced by the Lancefield group C strain of β-hemolytic streptococci (exotoxin), which activates the fibrinolytic system indirectly [20]. Streptokinase forms a 1:1 stoichiometric complex with plasminogen, which then undergoes a transition and exposes an active site in the modified plasminogen moiety, whereby the complex becomes a potent plasminogen activator.
Pharmacotherapy in complicated parapneumonic pleural effusions and thoracic empyema
2005, Pulmonary Pharmacology and TherapeuticsManagement of pleural infection in adults: British Thoracic Society pleural disease guideline 2010
2010, ThoraxCitation Excerpt :There is a report of adult respiratory distress syndrome in a patient who received both streptokinase and urokinase for empyema drainage.182 Doses of fibrinolytics used in studies have varied but include streptokinase 250 000 IU daily11 145 147–149 151–157 160 163 165 167 169 170 173–176 179 or 250 000 IU 12-hourly84 151 or urokinase 100 000 IU daily170 171 178 retained for 2–4 h in the pleural space. There is currently interest in other intrapleural agents including combination therapy with fibrinolytics and fluid viscosity and biofilm-disrupting agents such as streptodornase and deoxyribonuclease (DNase).183 184
Management of pleural effusions in the emergency department
2020, Reviews on Recent Clinical Trials
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Supported in part by the Ryan Hill Research Foundation, Seattle, Washington.
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Presented at the 77th Annual Meeting of the North Pacific Surgical Association, Seattle, Washington, November 9–10, 1990.
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From the Department of Surgery, Swedish and Virginia Mason Medical Centers, and the University of Washington, Seattle, Washington.