Clinical study
Variables associated with changes in spirometry in patients with obstructive lung diseases

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Abstract

One hundred fifty subjects were enrolled in a long-term study of obstructive lung diseases; 84 of these were subjected to five or more spirometric studies over a period of two or more years. Stepdown regression analysis was performed to determine the association between many different variables and the annual rates of change in the forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1). The following associations were noted to be significant (p < 0.03); more favorable rates of change of the FVC and FEV1 were associated with a higher alpha1-antitrypsin level and older age. Less favorable changes were associated with more years of cigarette smoking, more airway reactivity and more frequent lower respiratory tract illnesses.

References (27)

  • CH Stuart-Harris

    The role of bacterial and viral infection in chronic bronchitis

    Arch Environ Health

    (1968)
  • F Kueppers et al.

    Alpha1 antitrypsin and its deficiency

    Am Rev Rcspir Dis

    (1974)
  • RE Kanner et al.

    Pathologic patterns of chronic obstructive pulmonary disease in patients with normal and deficient levels of alpha1 antitrypsin

    Am J Med

    (1973)
  • B Burrows et al.

    Quantitative relationships between cigarette smoking and ventilatory function

    Am Rev Respir Dis

    (1977)
  • CR Lowe

    Chronic bronchitis and occupation

  • MW Higgins et al.

    Smoking, socioeconomic status, and chronic respiratory disease

    Am Rev Respir Dis

    (1977)
  • P Howard

    The changing face of chronic bronchitis with airways obstruction

    Br Med J

    (1974)
  • LC Neri et al.

    Chronic obstructive pulmonary disease in two cities of contrasting air quality

    Can Med Assoc J

    (1975)
  • AS Monto et al.

    The Tecumseh study of respiratory illness. Relation of acute infections to smoking, lung function and chronic symptoms

    Am J Epidemiol

    (1978)
  • Chronic bronchitis, asthma and pulmonary emphysema. A statement by the Committee on Diagnostic Standards for Non-tuberculous Respiratory Diseases

    Am Rev Respir Dis

    (1962)
  • U.S. Bureau of the Census

    Census of Population: 1970. General, Social, and Economic Characteristics

  • CB Laurell

    Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies

    Anal Biochem

    (1966)
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    This study was supported by NHLI Grant No. HL-14703 from the National Heart, Lung and Blood Institute, Bethesda, Maryland.

    1

    From the Department of Medicine and the Division of Biostatistics, University of Utah College of Medicine, Salt Lake City, Utah.

    Present address: 4589 El Cerrito Drive, San Diego, California 92115.

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