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Factors associated with mortality in patients with exacerbation of chronic obstructive pulmonary disease hospitalized in General Medicine departments

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Abstract

We aim to improve knowledge on risk factors that relate to mortality in subjects with exacerbation of chronic obstructive pulmonary disease (COPD) who are hospitalized in General Medicine departments. In a cross-sectional multicenter study, by means of a logistic regression analysis, we assessed the possible association of death during hospitalization with the following groups of variables of participating patients: sociodemographic features, treatment received prior to admission and during hospitalization, COPD-related clinical features recorded prior to admission, comorbidity diagnosed prior to admission, clinical data recorded during hospitalization, laboratory results recorded during hospitalization, and electrocardiographic findings recorded during hospitalization. A total of 398 patients was included; 353 (88.7%) were male, and the median age of the patients was 75 years. Of these patients, 21 (5.3%) died during hospitalization. Only 270 (67.8%) received inhaled β2 agonists during hospitalization, while 162 (40.7%) received angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers. The median of predicted FEV1 prior to admission was 42%. A total of 350 patients (87.9%) had been diagnosed with two or more comorbid conditions prior to admission. An association was found between increased risk of death during hospitalization and the previous diagnoses of pneumonia, coronary heart disease, and stroke. In conclusion, comorbidity is an important contributor to mortality among patients hospitalized in General Medicine departments because of COPD exacerbation.

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Author information

Authors and Affiliations

  1. Hospital General of Castellon, University of Valencia, Catalunya, 33-4, 12004, Castellon, Spain

    Bernardino Roca

  2. Hospital Mútua de Terrassa, Barcelona, Spain

    Pedro Almagro

  3. Hospital Vega Baja, Orihuela, Alicante, Spain

    Francisco López

  4. Hospital General, Universitario Gregorio Marañón, Madrid, Spain

    Francisco J. Cabrera

  5. Hospital Comarcal Axarquía, Vélez Málaga, Málaga, Spain

    Lorena Montero

  6. Hospital Universitario del Rio Hortega, Valladolid, Spain

    David Morchón

  7. Hospital Royo Villanova, Zaragoza, Spain

    Jesús Díez

  8. Hospital Juan Canalejo, La Coruña, Spain

    Fernando de la Iglesia

  9. Hospital General, Universitario 12 de Octubre, Madrid, Spain

    Mario Fernández

  10. Fundación Hospital Calahorra, La Rioja, Spain

    Jesús Castiella

  11. Hospital Donostia, San Sebastián, Spain

    Elena Zubillaga

  12. Hospital General, Universitari Vall d’Hebron, Barcelona, Spain

    Jesús Recio

  13. Fundación Caubet-Cimera, Centro Internacional de Medicina Respiratoria Avanzada, Baleares, Spain

    Joan B. Soriano

Authors
  1. Bernardino Roca
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  2. Pedro Almagro
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  3. Francisco López
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  4. Francisco J. Cabrera
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  5. Lorena Montero
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  6. David Morchón
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  7. Jesús Díez
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  8. Fernando de la Iglesia
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  9. Mario Fernández
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  10. Jesús Castiella
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  11. Elena Zubillaga
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  12. Jesús Recio
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  13. Joan B. Soriano
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Consortia

For the ECCO Working Group on COPD, Spanish Society of Internal Medicine

Corresponding author

Correspondence to Bernardino Roca.

Appendix

Appendix

Members of the ECCO Working Group on COPD were the following: Santiago Mola Caballero de Rodas, Francisco LópezGarcía, Jose Antonio CarrataláTorregrosa, Gemma PenadésCervera, Juan CustardoyOlavarrieta (Hospital Vega Baja-Orihuela, Alicante); Alberto MuelaMolinero, Juan Carlos Borrego Galán, (Hospital General de León); Rocío Llanos Llanos, María del Carmen GarcíaOrenes (Hospital Morales Meseguer, Murcia); Juan Manuel QuirogaIturralde, Gabriel ZubillagaGarmendia, Elena ZubillagaAzpiroz (Hospital de Donostia, San Sebastián); Mario FernándezRuiz (Hospital General Universitario 12 de Octubre, Madrid); JesúsRecioIglesias (Hospital General UniversitarioValld’Hebron, Barcelona); María del Carmen Martínez Velasco (Hospital San Juan de Dios, Pamplona); María Paz Pérez Gutiérrez (Hospital ClínicoUniversitario, Valladolid); Francisco Javier Cabrera Aguilar, Pablo Ryan Murua (Hospital General Universitario Gregorio Marañón, Madrid); Juan Antonio OrizMinuesa, Manuel Montero Pérez-Barquero (Hospital General Universitario Reina Sofía, Córdoba); JesúsCastiellaHerrero, Francisco José Sanjuan Portugal (Fundación Hospital Calahorra, La Rioja); Juan Lucio Ramos Salado, José Barquero Romero (ComplejoUniversitarioInfanta Cristina, Badajoz); Fernando Javier Sánchez Lora (Hospital de Antequera, Málaga); Angel HortalTavira (Hospital Virgen de Las Nieves, Granada); Jerónimo Nieto López Guerrero (Hospital de Cantoblanco, Madrid); María Cruz Almendros Rivas (Hospital de Palamos, Madrid); Fernando de la IglesiaMartinez (Hospital Juan Canalejo, A Coruña); Carlos Dueñas Gutiérrez (Hospital General Yagüe, Burgos); José Luis Lozano Polo (Hospital General Marqués de Valdecilla, Santander); DámasoEscribanoSevillano (Hospital de Jove, Gijón); Luis Quiroga Prado (Hospital de León); Carmen Mella Pérez (Hospital Vilagarcia de Arousa, Pontevedra); Ramón Cigüenza Gabriel (Hospital Clínico San Carlos, Madrid); José Portillo Sánchez (Hospital General de Ciudad Real); Ramon Boixeda i Viu (Hospital de Mataró, Barcelona); Lorena Montero Rivas, Carlos M San RománTerán (Hospital ComarcalAxarquía. VélezMálaga, Málaga); Joan CarlesTrullas Vila (Hospital San JaumeOlot, Gerona); Bernardino Roca Villanueva (Hospital General de Castellón); Julio Montes Santiago (Hospital Do Meixoeiro, Vigo); José Manuel Varela (Hospital Virgen del Rocío, Sevilla); David Morchón, Juan Carlos Martín Escudero (Hospital Universitario Rio Hortega, Valladolid); JesúsDíezManglán (Hospital Royo Villanova, Zaragoza); Elena Güell i Farré (ConsorciSanitari Integral, Barcelona); Olga AraújoLoperena (Hospital XarxaTecla, Tarragona); NuriaGalofré Alvaro (Hospital de Badalona); Beatriz Sobrino Diaz (Hospital General Universitario Carlos Haya, Málaga); Ana Belen Mecina Gutiérrez, María del Carmen Romero Pérez (Hospital de Leganés, Madrid); Patricia Crecente Otero, Laura Madrigal Cortés, Rubén Díez Bandera, Verónica Alvarez Alamo (Hospital ClínicoUniversitario, Salamanca); Pedro Almagro Mena (Hospital Mutua de Terrassa, Barcelona); Pablo Espejo Salamanca (Fundación Hospital de Manacor, Mallorca); Vicente GinerGalvañ (Hospital de Alcoy, Alicante); Rafael Castillo Rubio (Hospital La Malvarrosa, Valencia). All of them in Spain.

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Roca, B., Almagro, P., López, F. et al. Factors associated with mortality in patients with exacerbation of chronic obstructive pulmonary disease hospitalized in General Medicine departments. Intern Emerg Med 6, 47–54 (2011). https://doi.org/10.1007/s11739-010-0465-7

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