Skip to main content
SpringerLink
Log in

Activation of α-Latrotoxin Receptors in Neuromuscular Synapses Leads to a Prolonged Splash Acetylcholine Release

  • Biophysics and Biochemistry
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

The mechanisms of acetylcholine release in presynaptic terminals of motoneurons induced by mutant α-latrotoxin (LTN4C) were analyzed. In contrast to wild-type α-latrotoxin that causes both continuous and splash secretion of acetylcholine and necessarity block neuromuscular transmission, LTN4C causes only splash release lasting over many hours. Thus, activation of α-latrotoxin receptors controls long-lasting enhanced secretion of acetylcholine.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. A. C. Ashton, M. A. Rahman, K. E. Volynski, et al., Biochimie, 82, No. 5, 453-468 (2000).

    Article  CAS  PubMed  Google Scholar 

  2. M. Capogna, K. E. Volynski, N. J. Emptage, and Y. A. Ushkaryov, J. Neurosci., 23, No. 10, 4044-4053 (2003).

    CAS  PubMed  Google Scholar 

  3. K. Ichtchenko, M. Khvotchev, N. Kiyatkin, et al., EMBO J., 17, No. 21, 6188-6199 (1998).

    Article  CAS  PubMed  Google Scholar 

  4. E. V. Orlova, M. A. Rahman, B. Gowen, et al., Nat. Struct. Biol., 7, No. 1, 48-53 (2000).

    Article  CAS  PubMed  Google Scholar 

  5. L. Rosenthal and J. Meldolesi, Pharmacol. Ther., 42, No. 1, 115-134 (1989).

    Article  CAS  PubMed  Google Scholar 

  6. Y. Ushkaryov, Toxicon, 40, No. 1, 1-5 (2002).

    Article  CAS  PubMed  Google Scholar 

  7. Y. Ushkaryov, A. Rohou, and S. Siguta, Handb. Exp. Pharmacol., No. 184, 171-206 (2008).

  8. Y. A. Ushkaryov, K. E. Volynski, and A. C. Ashton, Toxicon, 43, No. 5, 527-542 (2004).

    Article  CAS  PubMed  Google Scholar 

  9. K. E. Volynski, M. Capogna, A. C. Ashton, et al., J. Biol. Chem., 278, No. 33, 31,058-31,066 (2003).

    Article  CAS  Google Scholar 

  10. K. E. Volynski, E. D. Nosyreva, Y. Ushkaryov, and E. V. Grishin, FEBS Lett., 442, No. 1, 25-28 (1999).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Cell and Molecular Biology, Imperial College, London, U.K.

    V. G. Lelyanova & Y. A. Ushkaryov

  2. Department of Neurosciences of Edinburg University, Edinburgh, U.K.

    D. Thomson & R. R. Ribchester

  3. Russian Research Institute of Sport and Physical Education, Moscow, Russia

    E. A. Tonevitsky

Authors
  1. V. G. Lelyanova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. Thomson
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. R. Ribchester
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. E. A. Tonevitsky
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Y. A. Ushkaryov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to E. A. Tonevitsky.

Additional information

Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 147, No. 6, pp. 639-641, June, 2009

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lelyanova, V.G., Thomson, D., Ribchester, R.R. et al. Activation of α-Latrotoxin Receptors in Neuromuscular Synapses Leads to a Prolonged Splash Acetylcholine Release. Bull Exp Biol Med 147, 701–703 (2009). https://doi.org/10.1007/s10517-009-0600-5

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-009-0600-5

Key Words

Search

Navigation