Abstract
We report a patient with a nonresectable histologically benign solitary fibrous tumor who suffered from paraneoplastic non-islet cell tumor hypoglycemia (NICTH). Diagnostic workup revealed malignant characteristics in which the tumor showed up as, presumably, false-negative on fluorodeoxyglucose-positron emission tomography (FDG-PET), while being positive on tyrosine-PET. Neoadjuvant treatment, which consisted of combined chemo-radiation and consecutive selective embolization of the tumor feeding vessels, caused such a therapeutic effect, on both NICTH and reduction in tumor volume, that a secondary resection, with the patient in a normoglycemic status, was possible. Our report highlights several important issues in the management of the patient with a nonresectable solitary fibrous tumor with severe episodes of hypoglycemia due to NICTH.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
PL Jager W Vaalburg J Pruim et al. (2001) ArticleTitleRadiolabeled amino acids: basic aspects and clinical applications in oncology J Nucl Med 42 432–445 Occurrence Handle11337520 Occurrence Handle1:CAS:528:DC%2BD3MXmvFOqt7k%3D
CD Fletcher P Dal Cin I de Wever et al. (1999) ArticleTitleCorrelation between clinicopathologic features and karyotype in spindle cell sarcomas: a report of 130 cases from the CHAMP study group Am J Pathol 154 1841–1847 Occurrence Handle10362810 Occurrence Handle1:STN:280:DyaK1M3ptlSgsw%3D%3D
E Bastiaannet H Groen PL Jager et al. (2004) ArticleTitleThe value of FDG-PET in the detection, grading and response to therapy of soft tissue and bone sarcomas; a systematic review and meta-analysis Cancer Treat Rev 30 83–101 Occurrence Handle14766127 Occurrence Handle10.1016/j.ctrv.2003.07.004 Occurrence Handle1:STN:280:DC%2BD2c%2FmsFWquw%3D%3D
CM Pezzi RE Pollock HL Evans et al. (1990) ArticleTitlePreoperative chemotherapy for soft-tissue sarcomas of the extremities Ann Surg 211 476–481 Occurrence Handle2157378 Occurrence Handle10.1097/00000658-199004000-00015 Occurrence Handle1:STN:280:By%2BB3M%2FnsVY%3D
SR Grobmyer RG Maki GD Demetri et al. (2004) ArticleTitleNeo-adjuvant chemotherapy for primary high-grade extremity soft tissue sarcoma Ann Oncol 15 1667–1672 Occurrence Handle15520069 Occurrence Handle10.1093/annonc/mdh431 Occurrence Handle1:STN:280:DC%2BD2crkslSktw%3D%3D
D Le Roith (1999) ArticleTitleTumor-induced hypoglycaemia N Engl J Med 341 757–758 Occurrence Handle10471466 Occurrence Handle10.1056/NEJM199909023411011 Occurrence Handle1:STN:280:DyaK1MzotlKhuw%3D%3D
LS Phillips DG Robertson (1993) ArticleTitleInsulin-like growth factors and non-islet cell tumor hypoglycaemia Metabolism 42 1093–1101 Occurrence Handle8412760 Occurrence Handle10.1016/0026-0495(93)90265-P Occurrence Handle1:CAS:528:DyaK3sXlsFOitbo%3D
MS Agus LE Katz M Satin-Smith et al. (1995) ArticleTitleNon-islet cell tumor associated with hypoglycaemia in a child: successful long-term therapy with growth hormone J Pediatr 127 403–407 Occurrence Handle7658270 Occurrence Handle10.1016/S0022-3476(95)70071-4 Occurrence Handle1:CAS:528:DyaK2MXotlWhtLg%3D
JD Teale V Marks (1998) ArticleTitleGlucocorticoid therapy suppresses abnormal secretion of big IGF-II by non-islet cell tumors inducing hypoglycaemia (NICTH) Clin Endocrinol (Oxf) 49 491–498 Occurrence Handle10.1046/j.1365-2265.1998.00564.x Occurrence Handle1:CAS:528:DyaK1cXnt1Gnu78%3D
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
de Boer, J., Jager, P., Wiggers, T. et al. The therapeutic challenge of a nonresectable solitary fibrous tumor in a hypoglycemic patient. Int J Clin Oncol 11, 478–481 (2006). https://doi.org/10.1007/s10147-006-0606-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10147-006-0606-1