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Role of sarco/endoplasmic reticulum calcium content and calcium ATPase activity in the control of cell growth and proliferation

  • Cell and Molecular Physiology
  • Published:
Pflügers Archiv - European Journal of Physiology Aims and scope Submit manuscript

Abstract

Ca2+, the main second messenger, is central to the regulation of cellular growth. There is increasing evidence that cellular growth and proliferation are supported by a continuous store-operated Ca2+ influx. By controlling store refilling, the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) also controls store-operated calcium entry and, thus, cell growth. In this review, we discuss data showing the involvement of SERCA in the regulation of proliferation and hypertrophy. First, we describe the Ca2+-related signaling pathways involved in cell growth. Then, we present evidence that SERCA controls proliferation of differentiated cells and hypertrophic growth of cardiomyocytes, and discuss the role of SERCA isoforms. Last, we consider the potential therapeutic applications of increasing SERCA activity for the treatment of cardiovascular diseases and of modulating SERCA and SR content for the treatment of cancer.

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Abbreviations

ATP:

adenosine triphosphate

Ca2+ :

ion calcium

CCE:

capacitative Ca2+ entry

CDK4:

cyclin-dependent kinase 4

CRAC:

calcium-release activated channel

CRACM1:

calcium-release activated channel molecule 1

IP3:

inositol-1,4,5-trisphosphate

IP3R:

inositol-1,4,5-trisphosphate receptor

NFAT:

nuclear factor of activated T-lymphocytes

PDGF:

platelet derived growth factor

PKC:

protein kinase C

Rb:

retinoblastoma protein

ROC:

receptor operated calcium channels

RyR:

ryanodine receptor

SR/ER:

sarco/endoplasmic reticulum

SERCA:

sarco/endoplasmic reticulum Ca2+ ATPase

SOC:

store-operated calcium channels

SRF:

serum response factor

STIM1:

stromal interaction molecule 1

TRPC:

transient receptor potential channels

VOCC:

voltage operated calcium channels

WT:

wild type

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  1. INSERM UMR S 621, Faculté de Médecine Pitié–Salpêtrière, Université Pierre et Marie Curie, 91, boulevard de l’Hôpital, Paris, F75013, France

    Larissa Lipskaia, Jean-Sébastien Hulot & Anne-Marie Lompré

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Lipskaia, L., Hulot, JS. & Lompré, AM. Role of sarco/endoplasmic reticulum calcium content and calcium ATPase activity in the control of cell growth and proliferation. Pflugers Arch - Eur J Physiol 457, 673–685 (2009). https://doi.org/10.1007/s00424-007-0428-7

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