Abstract
Ion mobility spectrometry, originally used to detect chemical warfare agents, explosives and illegal drugs, is now frequently applied in the field of process analytics. The method combines both high sensitivity (detection limits down to the ng to pg per liter and ppbv/pptv ranges) and relatively low technical expenditure with a high-speed data acquisition. In this paper, the working principles of IMS are summarized with respect to the advantages and disadvantages of the technique. Different ionization techniques, sample introduction methods and preseparation methods are considered. Proven applications of different types of ion mobility spectrometer (IMS) used at ISAS will be discussed in detail: monitoring of gas insulated substations, contamination in water, odoration of natural gas, human breath composition and metabolites of bacteria. The example applications discussed relate to purity (gas insulated substations), ecology (contamination of water resources), plants and person safety (odoration of natural gas), food quality control (molds and bacteria) and human health (breath analysis).
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References
Baumbach JI, Eiceman GA (1999) Appl Spectrosc 53:338A–355A
Eiceman GA, Karpas Z (1994) Ion mobility spectrometry. CRC, Boca Raton, FL, pp 1–228
Hill HH Jr, Siems WF, St Louis RH, McMinn DG (1990) Anal Chem 62:1201A–1209A
Roehl RE (1991) Appl Spectrosc Rev 26:1–57
Baumbach JI, Schmidt H, Sielemann S, Pilzecker PJ (2004) Process Anal Chem 8:1–20
Vautz W, Sielemann S, Baumbach JI (2004) Int J Ion Mobility Spectrom 7:18–23
Vautz W, Sielemann S, Uhde E, Baumbach JI (2004) Int J Ion Mobility Spectrom 7:30–34
Vautz W, Sielemann S, Baumbach JI (2003) Int J Ion Mobility Spectrom 6:21–29
Ruzsanyi V, Baumbach JI, Eiceman GA (2003) Int J Ion Mobility Spectrom 6:53–57
Li F, Eiceman GA, Ruzsanyi V, Baumbach JI (2003) Int J Ion Mobility Spectrom 6:64–66
Li F, Xie Y, Schmidt H, Sielemann S, Baumbach JI (2002) Spectrosc Spectral Anal (China) 372:606–610
Ruzsanyi V, Sielemann S, Baumbach JI (2002) Int J Ion Mobility Spectrom 5:45–48
Xie Z, Sielemann S, Schmidt H, Li F, Baumbach JI (2002) Anal Bioanal Chem 372:606–610
Soppart O, Pilzecker P, Baumbach JI, Klockow D, Trindade E (2000) IEEE T Dielect El In 7:229–233
Soppart O, Baumbach JI, Trindade E, Alberti SM, Moraes e Silva JM, Klockow D, Peier D (2000) Eur T Electr Power 10:179–184
Baumbach JI, Pilzecker P, Trindade E (1999) Int J Ion Mobility Spectrom 2:35–39
Xie Z, Sielemann S, Schmidt H, Baumbach JI (2001) Int J Ion Mobility Spectrom 4:77–83
Lubman DM (1988) Ion mobility spectrometry with laser-produced ions. In: Report ARO–2244416–CH. Gov Rep Announce Index (U.S.) 88(24) Abstr No 860641
Spangler GE (2000) Field Anal Chem Tech 4:255–267
Wu C, Hill HH Jr, Gamerdinger AP (1998) Field Anal Chem Technol 2:155–161
Spangler EG (2000) Field Anal Chem Technol 4:255–267
Bell SE, Ewing RG, Eiceman GA, Karpas ZJ (1994) Am Soc Mass Spectrom 5:177–185
Wu C, Hill HH, Rasulev UK, Nazarov EG (1999) Anal Chem 71:273–278
Schmidt H, Baumbach JI, Pilzecker P, Klockow D (2000) Int J Ion Mobility Spectrom 3:8–14
Tabrizchi M, Khayamian T, Taj N (2000) Rev Sci Inst 71:2321–2328
Borsdorf H, Rudolph M (2000) Int J Ion Mobility Spectrom 3:1–7
Borsdorf H, Schelhorn H, Rudolph M, Flachowsky J, Stach J (1999) Int J Ion Mobility Spectrom 2:40–44
Teepe M, Kang WJ, Neyer A, Baumbach JI, Schmidt H (2001) Int J Ion Mobility Spectrom 4(2):173–176
Leonhardt JW, Rohrbeck W, Bensch H (2000) Int J Ion Mobility Spectrom 3:43–49
Leonhardt JWJ (1995) Radioanal Nucl Chem 206:333–339
Leonhardt JW, Rohrbeck W, Bensch H (1995) In: Proc Fourth Int Workshop on Ion Mobility Spectrometry, 6–9 August 1995, Cambridge, UK
Sielemann S, Baumbach JI, Pilzecker P, Walendzik G (1999) Int J Ion Mobility Spectrom 2:15–21
Sielemann S, Baumbach JI, Schmidt H, Pilzecker P (2001) Anal Chim Acta 431:293–301
Kang WJ, Teepe M, Neyer A, Baumbach JI, Schmidt H, Sielemann S (2001) Int J Mobility Spectrom 4(2):108–111
Sielemann S, Li F, Schmidt H, Baumbach JI (2001) Int J Ion Mobility Spectrom 4(2):81–84
Vautz W, Ruzsanyi V, Sielemann S, Baumbach JI (2004) Int J Ion Mobility Spectrom 7:3–8
Leasure CS, Fleischer ME, Anderson GK, Eiceman GA (1986) Anal Chem 58:2142–2147
Shumate CB, Hill HH Jr (1989) Anal Chem 61:601–606
Baumbach JI, Pilzecker P, Trindade E (1999) Int J Ion Mobility Spectrom 2:35–39
Borsdorf H, Schelhorn H, Flachowski J, Döring HR, Stach J (2000) Anal Chem Acta 403:235–242
Xu J, Whitten WB, Lewis TA, Ramsey JM (2001) Int J Ion Mobility Spectrom 4(1):3–6
Borsdorf H, Schelhorn H, Flachowsky J, Döring H, Stach J (1999) Int J Ion Mobility Spectrom 2:9–14
Tabrizchi M, Khayamian T (2001) Int J Ion Mobility Spectrom 4:52–56
Tabrizchi M, Abedi A (2001) Int J Ion Mobility Spectrom 4(2):129–131
Tabrizchi M, Abedi A (2002) Int J Mass Spectrom 218:75–85
Hill CA, Thomas CLP (2003) Analyst 128:55–60
Hill C, Thomas P (2002) Int J Ion Mobility Spectrom 5:155–160
Baumbach JI, Soppart O, Pilzecker P, Trindade E, Klockow D (1999) Elektrizitätswirtschaft 3:37–42
Pilzecker P, Baumbach JI, Kurte R, Heise HM (2002) Int J Ion Mobility Spectrom 5:132–137
Walendzik G (2004) Dissertation. Universität Dortmund, Germany
Jauzein M, Baumbach JI, Gutierrez JI, Sardin M (1996) Measurement and modelling of VOC mobility in soils and groundwaters for environmental risk assessment. In: Barton J, Biletewski B, Büsing J, Jackson DV, Jager J, Jauzein M, Kresja P, Ujma KH (eds) Recycling technologies, treatment of waste and contaminated sites (DGXII/D-1). European Commission, Brussels, 15:361–371
Walendzik G, Baumbach JI, Sielemann S, Klockow D (1998) Proc Sixth Int Workshop on Ion Mobility Spectrometry, 10–14 August 1997, Bastei, Germany, p 326
Sielemann S, Teepe M, Vautz W, Baumbach JI (2004) GWF—Gas—Erdgas 145:642–646
Baumbach JI (2001) Uni-Report Universität Dortmund 33:44–48
Baumbach JI, Vautz W, Ruzsanyi V, Freitag L (2005) Metabolites in human breath: ion mobility spectrometers as diagnostic tools for lung diseases. In: Amann A, Smith D (eds) Breath gas analysis for medical diagnostics. World Scientific, Singapore
Baumbach JI, Vautz W, Ruzsanyi V, Freitag L (2005) Metabolites in human breath: ion mobility spectrometers as diagnostic tools for lung diseases. In: Knäblein J (ed) Modern biopharmaceuticals. Wiley–VCH, Weinheim
Ruzsanyi V (2005) Dissertation, Universität Dortmund, Germany
Acknowledgements
Major contributions to common experimental and laboratory work were made by Dr. Li Fang, Peter Pilzecker, Dr. Vera Ruzsanyi, Dr. Stefanie Sielemann, Dr. Gudrun Walendzik, Dr. Wolfgang Vautz and should be mentioned in gratitude. Some of the results discussed above were published partly in the PhD thesis of Dr. Gudrun Walendzik (water contamination) and Dr. Vera Ruzsanyi (breath analysis and metabolites of bacteria), and so they deserve hearty thanks. The co-operation and common experimental work done with G.A.S. Gesellschaft für analytische Sensorsysteme mbH, Dortmund, Germany, in the fields of applications of IMS to gas insulated substations and supervision of the odoration level of natural gas are gratefully acknowledged. Lucia Seifert, Stefanie Güssgen and the mechanical department of the ISAS headed by Hans–Georg Krebs made essential contributions to the results obtained. The co-operation, helpful discussions and support obtained at the Hemer lung hospital, especially from Dr. Lutz Freitag, Dr. Michael Westphal and Dr. Patrick Litterst, should also be mentioned. Additionally, detailed discussions on fundamental questions and application problems with Prof. Dr. Gary Eiceman, New Mexico State University, are gratefully acknowledged. The financial support of the Bundesministerium für Bildung und Forschung and the Ministerium für Wissenschaft und Forschung des Landes Nordrhein-Westfalen and the G.A.S. Gesellschaft für analytische Sensorsysteme mbH, Dortmund, is also gratefully acknowledged.
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Baumbach, J.I. Process analysis using ion mobility spectrometry. Anal Bioanal Chem 384, 1059–1070 (2006). https://doi.org/10.1007/s00216-005-3397-8
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DOI: https://doi.org/10.1007/s00216-005-3397-8