Abstract
Thymic stromal lymphopoietin (TSLP) primes dendritic cells to promote a Th2 inflammatory response. Its action is mediated by a heterodimeric receptor which consists of the interleukin-7 receptor α chain and the TSLP receptor chain (TSLPR). TSLPR resembles the common γ chain subunit utilized by many type 1 cytokine receptors. Normal epithelial cells, keratinocytes, and stromal cells constitutively express TSLP. Dendritic cells that are activated by TSLP promote the development of CD4+ T cells into pro-inflammatory Th2 cells. TSLP thus plays a potentially important role in the pathogenesis of allergic inflammation in asthma and atopic dermatitis. TSLP also has direct effects on other types of cells in the bronchial mucosa. It is over-expressed in the bronchial mucosa in chronic obstructive pulmonary disease (COPD), which is traditionally described as a Th1-related disease, as well as severe asthma, which is traditionally described as a Th2-related disease. In this review we will discuss TSLP expression, function, and available and potential mechanisms in both allergic inflammation and COPD.
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Abbreviations
- AD:
-
Atopic dermatitis
- BAL:
-
Bronchoalveolar lavage
- CCL:
-
Chemokine (C–C motif) ligand
- COPD:
-
Chronic obstructive pulmonary disease
- DC:
-
Dendritic cell
- DEP:
-
Diesel exhaust particle
- dsRNA:
-
Double-stranded ribonucleic acid
- HASMC:
-
Human airway smooth muscle cell
- HBEC:
-
Human bronchial epithelial cell
- IL:
-
Interleukin
- IL-7Rα:
-
IL-7 receptor α chain
- JAK:
-
Janus family tyrosine kinases
- LC:
-
Langerhans cell
- LPA:
-
Lysophosphatidic acid
- LTA:
-
Lipoteichoic acid
- MDC:
-
Macrophage-derived chemokine
- NF-κB:
-
Nuclear factor-κB
- NK:
-
Natural killer
- OX40L:
-
OX40 ligand
- poly I:C:
-
Polyinosinic:polycytidylic acid
- RSV:
-
Respiratory syncytial virus
- STAT:
-
Signal transducer and activator of transcription
- TARC:
-
Thymus activation-regulated chemokine
- Th:
-
T-helper
- TLR:
-
Toll-like receptor
- TNF:
-
Tumor necrosis factor
- Treg:
-
T-regulatory
- TSLP:
-
Thymic stromal lymphopoietin
- TSLPR:
-
TSLP receptor chain
- TSLP-DC:
-
TSLP-activated dendritic cell
- TSLP-LC:
-
TSLP-activated Langerhans cell
- γc :
-
Common γ chain
- VDR:
-
Vitamin D receptor
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Fang, C., Siew, L.Q.C., Corrigan, C.J. et al. The Role of Thymic Stromal Lymphopoietin in Allergic Inflammation and Chronic Obstructive Pulmonary Disease. Arch. Immunol. Ther. Exp. 58, 81–90 (2010). https://doi.org/10.1007/s00005-010-0064-3
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DOI: https://doi.org/10.1007/s00005-010-0064-3