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Perspectives of longitudinal growth in cystic fibrosis from birth to adult age

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Abstract

The longitudinal growth in 139 patients with cystic fibrosis (CF) was investigated from birth until the age of 19 years. Already at birth weight and length were reduced (weight: −0.83±0.13 SDS in girls, −0.44±0.13 SDS in boys; length: −0.55±0.13 SDS in girls, −0.39 ±0.14 SDS in boys; mean ± SEM). Both variables showed a further decline until diagnosis was established (weight: −1.57±0.21 SDS in girls, −1.46±0.25 SDS in boys; length: −1.15±0.32 SDS in girls, −1.03 ±0.52 SDS in boys; mean ± SEM). Six to 12 months after diagnosis length improved and reached the 25th percentile in both sexes. Height and weight followed the 25th percentile throughout childhood. Growth velocity was fairly normal during this period. There was a loss in percentiles of both height and weight after the age of 8 years and the pubertal growth spurt was delayed and reduced. However, the 25th percentile was reached again in the adolescent period. At the age of 19 years median height was 161,5 cm in girls and 173 cm in boys, both representing the 25th percentile. Using a sensitive statistical method for analysis of growth data we present CF specific growth curves for height, weight and growth velocity. There was no significant effect of pulmonary colonization withPseudomonas aeroginosa on growth velocity.

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Abbreviations

CF :

cystic fibrosis

SDS :

standard deviation score

References

  1. Barkhouse LB, Fahey J, Gillespie CT, Cole DEC (1989) Quantitating the effect of cystic fibrosis on linear growth by mathematic modelling of longitudinal growth curves. Growth, Dev Aging 53: 185–190

    Google Scholar 

  2. Berry HK, Kellogg FW, Hunt MM, et al (1975) Dietary supplement and nutrition in children with cystic fibrosis. Am J Dis Child 129: 165–171

    PubMed  Google Scholar 

  3. Byard PJ (1990) Early childhood growth in patients with cystic fibrosis. Ann Hum Biol 17: 483–499

    PubMed  Google Scholar 

  4. Corey M, Mc Laughlin FJ, Williams M, Levison HA (1988) Comparison of survival, growth, and pulmonary function in patients with cystic fibrosis in Boston and Toronto. J Clin Epidemiol 41: 583–591

    PubMed  Google Scholar 

  5. Dodge JA (1983) Nutrition. In: Hodson M, Norman AP, Batten JC (eds) Cystic fibrosis. Balilliere Tindall, London, pp 132–143

    Google Scholar 

  6. Green OC (1983) Endocrinological complications associated with cystic fibrosis. In: Still L, Wright J (eds) Textbook of cystic fibrosis. John Wright, London, pp 329–350

    Google Scholar 

  7. Healy M, Rasbash J (1988) Distribution-free estimation of age related centiles. Ann Hum Biol 15, 1: 17–22

    PubMed  Google Scholar 

  8. Holm S (1979) A simple sequentially rejective multiple test procedure. Scand J Statist 6: 65–70

    Google Scholar 

  9. Hsia DY (1959) Birth weight in cystic fibrosis of the pancreas. Ann Hum Genet 23: 289–295

    PubMed  Google Scholar 

  10. Huang N, Schidlow NH, Szatrowski T, Palmer J, et al (1987) Clinical features, survival rate, and prognostic factors in young adults with cystic fibrosis. Ann J Med 82: 871–879

    Google Scholar 

  11. Karlberg J, Kjellmer I, Kristiansson B (1991) Linear growth in children with cystic fibrosis. I. Birth to 8 years of age. Acta Peadiatr Scand 80: 508–514

    Google Scholar 

  12. Kerem E, Corey M, Gold R, Levison H (1990) Pulmonary function and clinical course in patients with cystic fibrosis after pulmonary colonization with Pseudomonas aeruginosa. J Pediatr 116: 714–719

    PubMed  Google Scholar 

  13. Kreißl T, Bender SW, Mörchen R, Hövels O (1972) The physical development of children with cystic fibrosis. Z Kinderheilkd 113: 93–110

    PubMed  Google Scholar 

  14. Landon C, Rosenfeld RG (1984) Short stature and pubertal delay in male adolescents with cystic fibrosis. Am J Dis Child 138: 388–391

    PubMed  Google Scholar 

  15. Lapey A, Kattwinkel J, Sant' Agnese PA di, Later L (1974) Steatorrhea and azotorrhea and their relation to growth and nutrition in adolescents and young adults with cystic fibrosis. J Pediatr 84: 328–334

    PubMed  Google Scholar 

  16. Mahaney MC, Mc Coy KS (1986) Developmental delays and pulmonary disease severity in cystic fibrosis. Hum Biol 58: 445–460

    PubMed  Google Scholar 

  17. Mearns BM (1983) Growth and development. In: Hodson M, Norman AP, Batten JC (eds) Cystic fibrosis, Bailliere Tindall, London, pp 183–196

    Google Scholar 

  18. Mitchell-Heggs, Mearns M, Batten JC (1976) Cystic fibrosis in adolescents and adults. Q J Med 45: 479–504

    PubMed  Google Scholar 

  19. Moshang T, Holsclaw DS (1980) Menarchal determinants in cystic fibrosis. Am J Dis Child 134: 1139–1142

    PubMed  Google Scholar 

  20. National research council (1989) Recommended dietary allowances, 10th edn., National Academy Press, Washington DC

    Google Scholar 

  21. Prader A, Largo RH, Molinari L, Issler C (1989) Physical growth of Swiss children from birth to 20 years of age. Helv Paediatr Acta [Suppl] 52: 1–125

    Google Scholar 

  22. SAS Language and Procedure (1990) Version 6. SAS Institute, Cary, USA

  23. Shepherd R, Cooksley WGE, Coole WDD (1980) Improved growth and clinical, nutritional and respiratory changes in response to nutritional therapy in cystic fibrosis. J Pediatr 97: 351–357

    PubMed  Google Scholar 

  24. Shwachman H, Kulczycki LL (1958) Long-term study of one hundred five patients with cystic fibrosis. Am J Dis Child 96: 6–15

    Google Scholar 

  25. Sproul A, Huang N (1964) Growth patterns in children with cystic fibrosis. J Pediatr 65: 664–675

    PubMed  Google Scholar 

  26. Tümmler B, Aschendorff A, Darnedde T, Fryburg K, Maass G, Hundrieser J (1990) Marker haplotype association with growth in German cystic fibrosis patients. Hum Genet 84: 267–273

    PubMed  Google Scholar 

  27. Wilcoxon F (1945) Individual comparison by ranking methods. Biometrics 1: 80–83

    Google Scholar 

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Haeusler, G., Frisch, H., Waldhör, T. et al. Perspectives of longitudinal growth in cystic fibrosis from birth to adult age. Eur J Pediatr 153, 158–163 (1994). https://doi.org/10.1007/BF01958975

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