Abstract
A patient with a cholesteatoma secondary to chronic suppurative otitis media developed infective complications including cerebellar and cerebellopontine abscesses.Burkholderia cepacia was isolated from ear swabs, infected tissue and surgical pus on five occasions over a six-month period. Despite exhibiting three different antibiotic susceptibility profiles, all five isolates were confirmed as clonally indistinguishable by pulsed-field gel electrophoresis. To the best of the authors' knowledge there are no previous reports ofBurkholderia cepacia causing infection of the adult central nervous system.
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Butler SL, Doherty CJ, Hughes JE, Nelson JW, Govan JRW:Burkholderia cepacia and cystic fibrosis: do natural environments present a potential hazard? Journal of Clinical Microbiology 1995, 33: 1001–1004.
Taplin D, Bassett DCJ, Mertz PM: Foot lesions associated withPseudomonas cepacia. Lancet 1971, ii: 568–571.
Berkelman RL, Lewin S, Allen JR, Anders RL, Budnick LD, Shapiro S, Friedman SM, Nicholas P, Holzman RS, Haley RW: Pseudobacteraemia attributed to contamination of povidone-iodine withPseudomonas cepacia. Annals of Internal Medicine 1981, 95: 32–36.
Craven DE, Moody B, Connoly MG, Kollisch NR, Stottmeier KD, Mccabe WR: Pseudobacteraemia caused by povidone-iodine solution contaminated withPseudomonas cepacia. New England Journal of Medicine 1981, 305: 621–623.
Sobel JD, Hashman N, Reinherz G, Merzbach D: NosocomialPseudomonas cepacia infection associated with chlorhexidine contamination. American Journal of Medicine 1982, 73: 183–186.
Wong S, Tam AY, Yung RW, Kwan EY, Tsoi NN:Pseudomonas septicaemia in apparently healthy children. Acta Paediatrica Scandinavica 1991, 80: 515–520.
Dailey RH, Benner EJ: Necrotizing pneumonitis due to the pseudomonad “Eugenic Oxidizer — Group I”. New England Journal of Medicine 1968, 279: 361–362.
Anonymous:Pseudomonas cepacia- more than a harmless commensal? Lancet 1992, 339: 1385–1386.
Nelson JW, Butler SL, Krieg D, Govan JRW: Virulence factors ofBurkholderia cepacia. FEMS Immunology and Medical Microbiology 1994, 8: 89–98.
Lacy DE, Spencer DA, Goldstein A, Weller PH, Darbyshire P: Chronic granulomatous disease presenting in childhood withPseudomonas cepacia septicaemia. Journal of Infection 1993, 27: 301–304.
Holmes B: The identification ofPseudomonas cepacia and its occurrence in clinical material. Journal of Applied Bacteriology 1986, 61: 299–314.
Basset DCJ: Wound infection withPseudomonas multivorans. Lancet 1970, i: 1188–1191.
Pallent LJ:Pseudomonas cepacia as contaminant and infective agent. Journal of Hospital Infection 1983, 4: 9–13.
Dettelbach MA, Hirsch BE, Weissman JL:Pseudomonas cepacia of the temporal bone: malignant external otitis in a patient with cystic fibrosis. Otolaryngology — Head and Neck Surgery 1994, 111: 528–532.
Basset DCJ, Dixon JAS, Hunt GH: Infection of Holter valve by Pseudomonas-contaminated chlorhexidine. Lancet 1973, i: 1263–1264.
Mandell GL, Douglas RG, Bennett JE: Principles and practice of infectious diseases. Churchill Livingstone, New York, 1990, p. 1682.
Stokes EJ, Ridgway GL, Wren MWD: Clinical microbiology. Edward Arnold, London, 1992, p. 239–250.
Kucers A, Bennett NM: The use of antibiotics. Heinemann Medical Books, Oxford, UK, 1987, p. 531–532.
Bryant RE, Hammond D: Interaction of purulent material with antibiotics used to treatPseudomonas infections. Antimicrobial Agents and Chemotherapy 1974, 6: 702–707.
Gold R, Jin E, Levison H, Isles A, Fleming P: Ceftazidime alone and in combination in patients with cystic fibrosis: lack of efficacy in treatment of severe respiratory infections caused byPseudomonas cepacia. Journal of Antimicrobial Chemotherapy 1983, 12, Supplement A: 331–336.
Lewin C, Doherty C, Govan J: In vitro activities of meropenem, PD 127391, PD 131628, ceftazidime, chloramphenicol, cotrimoxazole and ciprofloxacin againstPseudomonas cepacia. Antimicrobial Agents and Chemotherapy 1993, 37: 123–125.
Lorian V: Antibiotics in laboratory medicine. Williams & Wilkins, Baltimore, 1986, p. 978.
British Society for Antimicrobial Chemotherapy Working Party: A guide to sensitivity testing. Journal of Antimicrobial Chemotherapy 1991, 27, Supplement D: 22–29.
Anderson DJ, Kuhns JS, Vasil ML, Gerding DN, Janoff EN: DNA fingerprinting by pulsed-field gel electrophoresis and ribotyping to distinguishPseudomonas cepacia isolates from a nosocomial outbreak. Journal of Clinical Microbiology 1991, 29: 648–649.
Wilkinson SG, Pitt TL:Burkholderia (Pseudomonas) cepacia: surface chemistry and typing methods. Reviews in Medical Microbiology 1995, 6: 1–9.
Larsen GY, Stull TL, Burns JL: Marked phenotypic variability inPseudomonas cepacia isolated from a patient with cystic fibrosis. Journal of Clinical Microbiology 1993, 31: 788–792.
Cheng H-P, Lessie TG: Multiple replicons constituting the genome ofPseudomonas cepacia 17616. Journal of Bacteriology 1994, 176: 4034–4042.
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Hobson, R., Gould, I. & Govan, J. Burkholderia (Pseudomonas) cepacia as a cause of brain abscesses secondary to chronic suppurative otitis media. Eur. J. Clin. Microbiol. Infect. Dis. 14, 908–911 (1995). https://doi.org/10.1007/BF01691499
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DOI: https://doi.org/10.1007/BF01691499