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The investigation of linkage between a quantitative trait and a marker locus

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Abstract

Procedures are given, using sib pairs, for estimating linkage between a knownm-allele locus and a hypothesized two-allele locus that governs a quantitative trait. Random mating and linkage equilibrium are assumed. Also given are parametric and nonparametric methods for detecting linkage when the trait in question is governed by several two-allele loci, provided there is no epistasis.

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References

  • Cotterman, C. W. (1969). Factor-union phenotype systems. In Morton, N. E. (ed.),Computer Applications in Genetics, University of Hawaii Press, Honolulu, pp. 1–19.

    Google Scholar 

  • Graybill, F. A. (1961).An Introduction to Linear Statistical Models, McGraw-Hill, New York.

    Google Scholar 

  • Haseman, J. K. (1970). The genetic analysis of quantitative traits using twin and sib data. Unpublished Ph.D. thesis, University of North Carolina.

  • Haseman, J. K., and Elston, R. C. (1970). The estimation of genetic variance from twin data.Behav. Genet. 1: 11–20.

    PubMed  Google Scholar 

  • Kaplan, E. B., and Elston, R. C. (1972).A Subroutine Package for Maximum Likelihood Estimation (MAXLIK). Institute of Statistics Mimeo Series, University of North Carolina.

  • Kempthorne, O. (1957).An Introduction to Genetic Statistics, John Wiley, New York.

    Google Scholar 

  • Kendall, M. G. (1955).Rank Correlation Methods, Charles Griffin, London.

    Google Scholar 

  • Li, C. C. (1955).Population Genetics, University of Chicago Press, Chicago.

    Google Scholar 

  • Penrose, L. S. (1938). Genetic linkage in graded human characters.Ann. Eugen. 6: 133–138.

    Google Scholar 

  • Siegel, S. (1956).Nonparametric Statistics for the Behavioral Sciences McGraw Hill, New York.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina

    J. K. Haseman

  2. Department of Biostatistics and the Genetics Curriculum, University of North Carolina, Chapel Hill, North Carolina

    R. C. Elston

Authors
  1. J. K. Haseman
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  2. R. C. Elston
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Additional information

This investigation was supported by a U.S. Public Health Service Training Grant (2 T01 GM00038), Research Career Development Award (1-K3-GM-31,732), and a research grant (GM HD 16697) from the National Institute of General Medical Sciences.

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Haseman, J.K., Elston, R.C. The investigation of linkage between a quantitative trait and a marker locus. Behav Genet 2, 3–19 (1972). https://doi.org/10.1007/BF01066731

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  • DOI: https://doi.org/10.1007/BF01066731

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