Skip to main content
Log in

Detection of unruptured familial intracranial aneurysms by intravenous digital subtraction angiography

Screening of two affected families

  • Originals
  • Published:
Neuroradiology Aims and scope Submit manuscript

Summary

The authors discuss the detection of intracranial aneurysms (IA) by means of intravenous digital angiography (ivDSA) in (a)symptomatic first degree relatives of families in which two or more individuals have IA. ivDSA is an almost noninvasive and low-risk diagnostic procedure. Screening, by means of ivDSA, of two affected families is described. In family I which includes 7 members with proven IA, ivDSA has been carried out in 36 asymptomatic individuals: in one, a 6x15 mm aneurysm was found at the left posterior communicating artery (PCoA). In family II, including one member with a proven IA and another with a subarachnoid hemorrhage, ivDSA has been carried out in 4 members: one aneurysm with a diameter of 6 mm was found at the left PCoA. Conventional cerebral angiography (CCA) confirmed both IA's. Neurosurgical treatment followed. The advantages and disadvantages of ivDSA vs. CCA as elective screening procedure in such cases are discussed. Screening of asymptomatic first degree relatives of cases with familial IA by means of ivDSA is strongly advocated.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Ambrosetto P, Galassi E (1981) Familial occurrence of multiple intracranial aneurysms. Case reports and review of the literature. Acta Neurochir 56: 233–238

    Google Scholar 

  2. ter Berg JWM, Bijlsma JB, Veiga Pires JA, Ludwig JW, van der Heiden C, Tulleken CAF, Willemse J (1986) Familial association of intracranial aneurysms and multiple congenital anomalies. Arch Neurol 43: 30–34

    Google Scholar 

  3. Fox JL, Ko JP (1980) Familial intracranial aneurysms. Six cases among 13 siblings. J Neurosurg 52: 501–503

    Google Scholar 

  4. Hashimoto I (1977) Familial intracranial aneurysms and cerebral vascular anomalies. J Neurosurg 46: 419–427

    Google Scholar 

  5. Duff ThA, Turski PA, Sackett JF, Strother CM, Crummy AB (1982) Evolving role of digital subtraction angiography in neurosurgical practice. Neurosurg 11: 430–438

    Google Scholar 

  6. Enzmann DR, Brody WR, Riederer S, Keyes G, Collins W, Pele N (1982) Intracranial intravenous digital subtraction angiography. Neuroradiol 23: 241–251

    Google Scholar 

  7. De Filipp GJ, Pinto RS, Lin JP, Kricheff II (1983) Intravenous digital subtraction angiography in the investigation of intracranial disease. Radiol 148: 129–136

    Google Scholar 

  8. Little JR, Furlan AJ, Modic MT, Weinstein MA (1982) Digital subtraction angiography in cerebrovascular disease. Stroke 13: 557–566

    Google Scholar 

  9. Furlan NJ, Weinstein MA, Little JR, Modic MT (1983) Digital subtraction angiography in the evaluation of cerebrovascular disease. Neurologic Clinics, vol 1, no 1, WB Saunders 55–72

    Google Scholar 

  10. Andrews RJ (1977) Intracranial aneurysms: characteristics of aneurysms in siblings. New Engl J Med 297: 115

    Google Scholar 

  11. Kassell NF (1983) Comments. Neurosurg 12: 215–216

    Google Scholar 

  12. Morooka Y, Waga S (1983) Familial intracranial aneurysms: report of four families. Surg Neurol 19: 260–262

    Google Scholar 

  13. Jain KK (1974) Familial intracranial aneurysms. Acta Neurochir 30: 129–137

    Google Scholar 

  14. Patrick D, Appleby A (1983) Familial intracranial aneurysm and infundibular widening. Neuroradiol 25: 329–334

    Google Scholar 

  15. Stavenow L (1979) Familial occurrence of intracranial aneurysms. Acta Med Scand 206: 197–200

    Google Scholar 

  16. Brisman R (1971) Familial intracranial aneurysms. J Neurosurg 34: 678–682

    Google Scholar 

  17. Edelsohn L (1972) Familial aneurysms and infundibular widening. Neurology 22: 1056–1060

    Google Scholar 

  18. Earnest F, Forbes G, Sandok BA, Piepgras DG, Faust RJ, Ilstrup DM, Arndt LJ (1983) Complications of cerebral angiography: prospective assessment of risk. AJNR 4: 1194–1197

    Google Scholar 

  19. Mani RL, Eisenberg RL, McDonald EJ, Pollock JA, Mani JR (1978) Complications of catheter cerebral arteriography: analysis of 5000 procedures. I. Criteria and incidence. AJR 131: 861–865

    Google Scholar 

  20. Eisenberg RL, Bank WO, Hedgcock MW (1980) Neurologic complications of angiography for cerebrovascular disease. Neurology 30: 895–897

    Google Scholar 

  21. Faught E, Trader SD, Hanna GR (1979) Cerebral complications of angiography for transient ischemia and stroke: prediction of risk. Neurology 29: 4–15

    Google Scholar 

  22. Ball JB, Lukin RR, Tomsick ThA, Chambers AA (1985) Complications of intravenous digital subtraction angiography. Arch Neurol 42: 969–972

    Google Scholar 

  23. Ghoshhajra K, Scotti L, Marasco J (1979) CT detection of intracranial aneurysms in subarachnoid hemorrhage. AJR 132: 613–616

    Google Scholar 

  24. Schubiger O, Valavamis A, Hayek J (1980) Computed tomography in cerebral aneurysms with special emphasis on giant intracranial aneurysms. J Comput Assist Tomogr 4: 24–32

    Google Scholar 

  25. Endtz J (1968) Familial incidence of intracranial aneurysms. Acta Neurochir 19: 297–305

    Google Scholar 

  26. Halal F, Mohr G, Toussi T, Martinez SM (1983) Intracranial aneurysms: a report of a large pedigree. Am J Med Gen 15: 89–95

    Google Scholar 

  27. Allcock JM, Canham PB (1976) Angiographic study of the growth of intracranial aneurysms. J Neurosurg 45: 617–621

    Google Scholar 

  28. Moyes PD (1971) Surgical treatment of multiple aneurysms and of incidentally-discovered unruptured aneurysms. J Neurosurg 35: 291–295

    Google Scholar 

  29. Mount LA, Brisman R (1971) Treatment of multiple intracranial aneurysms. J Neurosurg 35: 728–730

    Google Scholar 

  30. Crompton MR (1966) Mechanisms of growth and rupture in cerebral berry aneurysms. Brit Med J 1: 1138–1142

    Google Scholar 

  31. Freytag E (1966) Fatal rupture of intracranial aneurysms. Arch Path 81: 418–424

    Google Scholar 

  32. Locksley HB (1966) Report on the cooperative study of intracranial aneurysms and subarachnoid hemorrhage, intracranial aneurysms and arteriovenous malformations. J Neurosurg 25: 321–368

    Google Scholar 

  33. Ojeman RG (1981) Management of the unruptured intracranial aneurysm. New Engl J Med 304: 725–726

    Google Scholar 

  34. Ferguson GG, Peerless SJ, Drake CG (1981) Natural history of intracranial aneurysms. New Engl J Med 305: 99

    Google Scholar 

  35. Wiebers DO, Whisnant JP, O'Fallon WM (1981) The natural history of unruptured intracranial aneurysms. New Engl J Med 304: 696–698

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

ter Berg, J.W.M., Overtoom, T.M.D., Ludwig, J.W. et al. Detection of unruptured familial intracranial aneurysms by intravenous digital subtraction angiography. Neuroradiology 29, 272–276 (1987). https://doi.org/10.1007/BF00451766

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00451766

Key words

Navigation