Regular ArticleAssociation of the Serotonin Transporter Gene with Serum Cholesterol Levels and Heart Disease
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Cited by (58)
SLC6A4 polymorphisms and age of onset in late-life depression on treatment outcomes with citalopram: A sequenced treatment alternatives to relieve depression (STAR∗D) report
2014, American Journal of Geriatric PsychiatryCitation Excerpt :A recent report by Alexopoulos et al37 found that elderly depressed S-allele carriers had more microstructural white matter abnormalities in the frontolimbic system and lower remission rates than L-allele carriers. The presence of SL-allele status was associated with increased cholesterol, triglycerides, and risk for heart disease, angina, and heart attacks in individuals aged 50–70 years.38 Moreover, S-allele carriers had a higher probability of cardiac events after an acute myocardial infarction including cardiac death, revascularization, heart failure, reinfarction, arrhythmia, and unstable angina than L homozygotes.39
A genetically informed test of cholesterol levels and self-control, depressive Symptoms, antisocial behavior, and neuroticism
2014, Journal of Affective DisordersCitation Excerpt :A complementary line of research seems to implicate the neurotransmitter serotonin as a significant mediating factor in such associations (Kaplan et al., 1997). Despite partial support for the serotonin–cholesterol hypothesis (Asellus et al., 2010; Buydens-Branchey et al., 2000; Comings et al., 1999; Kim et al., 2011; Marčinko et al., 2007; Scanlon et al., 2001), the potential underlying etiology of the association between cholesterol levels and various deleterious outcomes remains largely unknown. One possible, yet unexplored, explanation of such associations is a shared genetic etiology in which genetic influences significantly contribute to both cholesterol levels and various outcomes.
The neurobiology of depression in later-life: Clinical, neuropsychological, neuroimaging and pathophysiological features
2012, Progress in NeurobiologyDepression and cardiovascular disorders
2012, Handbook of Clinical NeurologyCitation Excerpt :Regarding common genes, the length polymorphism of the serotonin transporter (5-HTT) is a candidate. The polymorphism of this gene is not only related to the risk for affective disorders in a complex gene–environmental manner (Caspi et al., 2003): the 5-HTT length polymorphism has also been related to risk factors for cardiovascular disease, both by lipid metabolism and by platelet activity (Comings et al., 1999; Whyte et al., 2001). Thus, it is not surprising that this polymorphism could be related to depression as well as to cardiac events in patients with acute MI (Nakatani et al., 2005).
The relationship between serotonin transporter gene promoter polymorphism and serum lipid levels at young age in a longitudinal population-representative study
2011, Progress in Neuro-Psychopharmacology and Biological PsychiatryCitation Excerpt :The findings concerning the levels of blood lipids and 5-HTTLPR have not, however, always been consistent even in elderly populations. A study on non-Hispanic Caucasians (mean age of 55.4 ± 7.5 years) from the Loma Linda University Centre for Health Promotion, California (Comings et al., 1999) reported that total cholesterol and triglyceride levels were significantly higher in s/l heterozygotes than either in s/s or l/l homozygotes. However, that study consisted of a very limited sample, 99 subjects in total.
Cholesterol and serotonin transporter polymorphism interactions in late-life depression
2011, Neurobiology of Aging
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