Journal of Molecular Biology
Volume 293, Issue 3, 29 October 1999, Pages 449-455
CommunicationA 2.6 å structure of a serpin polymer and implications for conformational disease1
Section snippets
Protein data bank number
Coordinates have been deposited in the Protein Data Bank (accession number 18mb).
Acknowledgements
We thank Charles T. Esmon for providing the inactive thrombin. This work was supported by the Wellcome Trust (R.W.C., 039046; R.J.R. 050211) and by the NIH (J.A.H. HL09927). N.S.P. is supported by Wellcome Trust and NSERC studentships.
References (32)
- et al.
Immunochemical identification of the serine protease inhibitor α1-antichymotrypsin in the brain amyloid deposits of Alzheimer’s disease
Cell
(1988) - et al.
A fast algorithm for rendering space-filling molecule pictures
J. Mol. Graph.
(1988) - et al.
Conformational disease
Lancet
(1997) - et al.
Protein hydration observed by X-ray diffraction. Solvation properties of penicillopepsin and neuraminidase crystal structures
J. Mol. Biol.
(1994) - et al.
Human α1-proteinase inhibitor. Crystal structure analysis of two crystal modifications, molecular model and preliminary analysis of the implications for function
J. Mol. Biol.
(1984) - et al.
α1-Antitrypsin Siiyama (Ser53→Phe). Further evidence for intracellular loop-sheet polymerization
J. Biol. Chem.
(1993) A visual protein crystallographic software system for X11/XView
J. Mol. Graph.
(1992)Model phasesprobabilities and bias
Methods Enzymol.
(1997)- et al.
Interfering with the inhibitory mechanism of serpinscrystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide
Structure
(1998) - et al.
Domain swappingentangling alliances between proteins
Proc. Natl Acad. Sci. USA
(1994)
Crystallography & NMR systema new software suite for macromolecular structure determination
Acta Crystallog. sect. D
(1998)
Probing serpin reactive-loop conformations by proteolytic cleavage
Biochem. J.
(1996)
Importance of the release of strand 1C to the polymerization mechanism of inhibitory serpins
Protein Sci.
(1997)
The CCP4 suiteprograms for protein crystallography
Acta Crystallog. sect. D
(1994)
Inhibitory conformation of the reactive loop of α1-antitrypsin
Nature Struct. Biol.
(1996)
The S variant of human α1-antitrypsin, structure and implications for function and metabolism
Protein Eng.
(1989)
Cited by (120)
The identification of a serpin with immune defense role in oriental river prawn Macrobrachium nipponense
2024, International Journal of Biological MacromoleculesSerpin-type serine protease inhibitor mediates coelomocyte apoptosis in Apostichopus japonicus
2020, Fish and Shellfish ImmunologyAlpha1-Antitrypsin: Structure and Dynamics in Health, Disease and Drug Development
2017, Alpha-1-antitrypsin Deficiency: Biology, Diagnosis, Clinical Significance, and Emerging TherapiesMolecular Mechanisms of Protein Misfolding
2013, Bio-nanoimaging: Protein Misfolding and Aggregation
- 1
Edited by R. Huber
Copyright © 1999 Academic Press. All rights reserved.