Short CommunicationDIFFERENCES IN THE GENOTYPES AND PLASMA CONCENTRATIONS OF THE INTERLEUKIN-1 RECEPTOR ANTAGONIST IN BLACK AND WHITE SOUTH AFRICAN ASTHMATICS AND CONTROL SUBJECTS
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Cited by (23)
Beyond single-nucleotide polymorphisms: Genetics, genomics, and other 'omic approaches to acute respiratory distress syndrome
2014, Clinics in Chest MedicineCitation Excerpt :However, an alternative perspective is to consider ARDS as a pattern of response to injury, be it pneumonia, sepsis, or trauma. As a trait, the response to injury has significant heritability.3–7 In fact, death from infection was the most heritable condition when studied in a large Danish registry of adoptees, with a much stronger heritability than vascular disease or cancer.8
High risk association of IL-1 receptor antagonist (IL-1RN) VNTR polymorphism with asthma in a North Indian population: A pilot study
2013, CytokineCitation Excerpt :Furthermore, a Japanese study also reports no association of this polymorphism with COPD [38]. A research conducted on South African White and Black asthmatic populations also reports no significant association of IL-1RN VNTR polymorphism and asthma [39]. Similar results were observed for a study conducted on a Taiwanese asthmatic population as well, thereby negating any association with asthma [40].
Impact of glutathione-S-transferase gene polymorphisms on enzyme activity, lung function and bronchial asthma susceptibility in Egyptian children
2012, GeneCitation Excerpt :Asthma is a complex disorder involving genetic and environmental factors. Many candidate genes related to the development of asthma and atopy have been identified, and different genes may be involved in different ethnic groups (Ober et al., 2000; Pillay et al., 2000). There is an increasing evidence that asthma is associated with increased oxidative stress (Mak et al., 2004).
Polymorphism in intron 2 of the interleukin-1 receptor antagonist gene, local midtrimester cytokine response to vaginal flora, and subsequent preterm birth
2004, American Journal of Obstetrics and GynecologyCitation Excerpt :The IL1RN∗2 variant has been previously associated with a diminished IL-1β response to inciting stimuli under some circumstances.14,15 This study also confirms that the IL1RN∗2 carriage rate is 10% to 30% less among black, compared with white and Hispanic subjects.5,16 In the United States, the risk for spontaneous preterm delivery is twice as high in black as white women, even after controlling for demographic and behavioral factors.17
Association of GST genes polymorphisms with asthma in Tunisian children
2007, Mediators of InflammationIl-1rn vntr, il-2(-330), and il-4 vntr gene polymorphisms in patients with chronic rhinosinusitis with sinonasal polyposis
2019, Turkish Journal of Medical Sciences
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Correspondence to: M.-C. Gaillard, Department of Medicine University of the Witwatersrand, 7 York Road, Parktown, Johannesburg, South Africa; E-mail:[email protected]