Clinical Immunology and Immunopathology
Regular ArticleT Lymphocyte Subpopulations and Activation Markers Correlate with Severity of Alzheimer's Disease
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A glance through the effects of CD4<sup>+</sup> T cells, CD8<sup>+</sup> T cells, and cytokines on Alzheimer's disease
2023, Computational and Structural Biotechnology JournalCrossing borders in Alzheimer's disease: A T cell's perspective
2022, Advanced Drug Delivery ReviewsImmune function in X-linked retinoschisis subjects in an AAV8-RS1 phase I/IIa gene therapy trial
2021, Molecular TherapyCitation Excerpt :Increased CD4/CD8 ratios generally are associated with conditions of chronic autoimmunity and inflammation.26–28 Dysregulation of the T cell ratio is reported for multiple sclerosis, sarcoidosis, and Alzheimer’s disease, and also in elderly subjects.29–31 Females generally have higher CD4/CD8 ratios than do males, which may predispose them toward autoimmune diseases.32,33
Neuroimmune interactions in Alzheimer's disease—New frontier with old challenges?
2019, Progress in Molecular Biology and Translational ScienceCitation Excerpt :Besides the impact of the innate immune system, evidence exists that the adaptive arm of the immune system also may play a role in neurodegenerative diseases. Changes in T cell subtypes, as well as B cells, have been reported in peripheral blood of AD patients compared to controls109–117 and it has been speculated that a general aging of the immune system may predispose to development of neurodegenerative diseases.118,119 While major lymphocyte infiltrations are not a feature of neurodegenerative diseases, focal infiltrates of lymphocytes have been observed in brains of AD patients and murine model systems.120–123
Intracranial IL-17A overexpression decreases cerebral amyloid angiopathy by upregulation of ABCA1 in an animal model of Alzheimer's disease
2017, Brain, Behavior, and ImmunityCitation Excerpt :Lymphocytes in the CNS are replenished by newly immigrating cells approximately twice per day (Engelhardt and Ransohoff, 2005; Hickey, 2001; Smolders et al., 2013). Numerous lines of evidence indicate the presence of T cells in the brains of AD patients (Ferretti et al., 2016; Lombardi et al., 1999; Monsonego et al., 2003; Shalit et al., 1995; Togo et al., 2002) although their possible roles in AD pathogenesis have been studied less than those of microglia. T cells in the brains of AD patients increased as compared with subjects with non-AD degenerative dementias and age-matched controls (Lueg et al., 2015; Togo et al., 2002).
Increased frequency of T cells expressing IL-10 in Alzheimer disease but not in late-onset depression patients
2013, Progress in Neuro-Psychopharmacology and Biological Psychiatry