Clinical Immunology and Immunopathology
Regular ArticleChanges in Cytokine Production after Measles Virus Vaccination: Predominant Production of IL-4 Suggests Induction of a Th2 Response
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Expression kinetics of ISG15, IRF3, IFNγ, IL10, IL2 and IL4 genes vis-a-vis virus shedding, tissue tropism and antibody dynamics in PPRV vaccinated, challenged, infected sheep and goats
2018, Microbial PathogenesisCitation Excerpt :The PPRV unvaccinated infected animals exhibited a better Th1 response (increased IFN gamma) than the vaccinated animals of both the species. It is established that generation of a Th1 response is less efficient after vaccination than natural infection [40] [39]. The higher expression of IL10 at 9 dpi in both the species indicated immunosuppression at peak viral load.
Measles Vaccines
2017, Plotkin's VaccinesUnravelling the nature of non-specific effects of vaccines—A challenge for innate immunologists
2016, Seminars in ImmunologyCitation Excerpt :No studies have examined possible epigenetic reprogramming after OPV vaccination as explanation for some of its epidemiological effects. Measles vaccine (MV) has shown a general but transient suppressive effect on both the lymphoproliferative and innate response evaluated in PBMCs from children [67–69]. One immunological study in infants nested within a RCT found higher plasma levels of MCP-1 and IL-1 receptor agonist(ra) after MV in females, whereas in males the effect was only moderately positive for MCP-1.
Can vaccines interact with drug metabolism?
2015, Pharmacological ResearchCitation Excerpt :A role for immune modulation in interactions with drugs was unveiled, based on several converging pieces of evidence. Vaccine immunisation elicits an immune response that mimics the response to the natural disease in order to provide protection against subsequent challenges, including the production of cytokines such as interferon-γ (INFγ) [19,20]. A major role of inflammatory cytokines as regulators of the expression of members of the cytochrome P450 family of oxidising enzymes (CYPs) was described in the liver.
Measles vaccine
2012, Vaccines: Sixth EditionImmunological impact of an additional early measles vaccine in Gambian children: Responses to a boost at 3 years
2012, VaccineCitation Excerpt :They may be more susceptible to subclinical infections [20] though this event is unlikely to result in the further spread of measles [21]. CD8 T-cells are necessary to control measles viraemia [16] and the role and importance of cytotoxic T-cell responses, cellular proliferative responses and cytokine responses during and after measles or primary vaccination have been thoroughly described [15,22,23]. However, very little is known of these responses shortly after booster vaccination or natural exposure in immunized children.