Regular ArticleAdenoviral-Mediated Gene Transfer of Interleukin-6 in Rat Lung Enhances Antiviral Immunoglobulin A and G Responses in Distinct Tissue Compartments☆
References (13)
- et al.
Immunol. Today
(1994) - et al.
Cytokines of the Lung
(1993) - et al.
J. Immunol.
(1994) - et al.
J. Immunol.
(1993) - et al.
Cited by (7)
Systemic interleukin-6 responses following administration of adenovirus gene transfer vectors to humans by different routes
2002, Molecular TherapyCitation Excerpt :Many cell types, including monocytes, alveolar macrophages, endothelial cells, fibroblasts, mesangial cells, keratinocytes, B and T lymphocytes, and dendritic cells, produce IL-6 in response to a variety of stimuli [18–20,23]. Among the diverse functions of IL-6 include regulation of the terminal steps of B-cell differentiation, stimulation of B-cell IgG synthesis, stimulation of T-cell proliferation and induction of cytotoxic T-lymphocyte activity by peripheral and thymic T-cell precursors [20,23,31,32]. Studies in experimental animals have demonstrated that, following Ad vector-mediated gene transfer to several organs, a combination of innate and acquired host immune responses preclude stable gene expression [4–19].
Cigarette Smoke Decreases Pulmonary Dendritic Cells and Impacts Antiviral Immune Responsiveness
2004, American Journal of Respiratory Cell and Molecular BiologyGene therapy and gene transfer approaches for acute lung injury
2002, Gene Therapy in Lung DiseaseUse of gene transfer to study lung: Cytokine biology
2002, Gene Therapy in Lung Disease
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Kelly, J.
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To whom correspondence and reprint requests should be addressed at Rm. 4H13, Health Science Centre, Department of Pathology, McMaster University, Hamilton, Ontario, L8N 3Z5 Canada. Fax: 905-522-6750. E-mail:[email protected].