Regular Article
Oxidative Stress, Human Genetic Variation, and Disease

https://doi.org/10.1006/abbi.2001.2295Get rights and content

Abstract

Oxidative stress has been implicated in numerous pathophysiological conditions and also aging. The tools for studying oxidative stress are now expanding as a result of the human genome effort and, in particular, expanding knowledge on human genetic variation. A few genetic variants, mostly in the form of single nucleotide polymorphisms of relevance to oxidative stress are already studied by a molecular epidemiologic approach. A review of the current knowledge on variant human genes that are directly implicated in human protection against oxidative stress is presented.

References (145)

  • J.M. Mates et al.

    Clin. Biochem.

    (1999)
  • A.J. Brookes

    Gene

    (1999)
  • T. Emahazion et al.

    Gene

    (1999)
  • M. Krawczak et al.

    Trends Genet.

    (1997)
  • L. Forsberg et al.

    Free Radic. Biol. Med.

    (2001)
  • K. Abe et al.

    J. Neurol. Sci.

    (1996)
  • Y.S. Ho et al.

    J. Biol. Chem.

    (1998)
  • W. Beyer et al.

    Prog. Nucleic Acid Res. Mol. Biol.

    (1991)
  • S.L. Church et al.

    Genomics

    (1992)
  • S. Shimoda-Matsubayashi et al.

    Biochem. Biophys. Res. Commun.

    (1996)
  • S. Hiroi et al.

    Biochem. Biophys. Res. Commun.

    (1999)
  • Y.S. Ho et al.

    FEBS Lett.

    (1988)
  • D.J. Hendrickson et al.

    Genomics

    (1990)
  • J. Sandstrom et al.

    J. Biol. Chem.

    (1994)
  • T. Adachi et al.

    Clin. Chim. Acta

    (1992)
  • J.A. Moscow et al.

    J. Biol. Chem.

    (1992)
  • Q. Shen et al.

    Genomics

    (1994)
  • L.U. Forsberg et al.

    Blood Cells Mol. Dis.

    (2000)
  • Y.S. Ho et al.

    J. Biol. Chem.

    (1997)
  • J.B. de Haan et al.

    J. Biol. Chem.

    (1998)
  • F.F. Chu et al.

    J. Biol. Chem.

    (1993)
  • F.F. Chu et al.

    Genomics

    (1996)
  • R. Brigelius-Flohe

    Free Radic. Biol. Med.

    (1999)
  • F. Ursini et al.

    Biochim. Biophys. Acta

    (1985)
  • J.P. Thomas et al.

    Biochim. Biophys. Acta

    (1990)
  • M. Arai et al.

    J. Biol. Chem.

    (1999)
  • M.J. Kelner et al.

    Biochim, Biophys. Res. Commun.

    (1998)
  • Y. Saito et al.

    J. Biol. Chem.

    (1999)
  • K.E. Hill et al.

    J. Biol. Chem.

    (1991)
  • K.E. Hill et al.

    Genomics

    (1996)
  • J.K. Wen et al.

    J. Mol. Biol.

    (1990)
  • A. Hirono et al.

    Blood Cells Mol. Dis.

    (1995)
  • K. Tsuchiya et al.

    Genomics

    (1995)
  • E. Beutler et al.

    Blood

    (1999)
  • G.C. Webb et al.

    Genomics

    (1995)
  • H. Ahmad et al.

    Arch. Biochem. Biophys.

    (1990)
  • F. Ali-Osman et al.

    J. Biol. Chem.

    (1997)
  • B. Halliwell

    Br. J. Exp. Pathol.

    (1989)
  • J.A. Knight

    Ann. Clin. Lab. Sci.

    (1998)
  • H. Sies

    Advances in Pharmacology

    (1997)
  • H. Sies

    Oxidative Stress, Oxidants and Antioxidants

    (1991)
  • S. Melov et al.

    Science

    (2000)
  • K. Irizarry et al.

    Nat. Genet.

    (2000)
  • L. Forsberg et al.

    Tech. Tips Online

    (1998)
  • L. Forsberg et al.

    Hum. Mutat.

    (1999)
  • D.G. Wang et al.

    Science

    (1998)
  • L. Picoult-Newberg et al.

    Genome Res.

    (1999)
  • K.H. Buetow et al.

    Nat. Genet.

    (1999)
  • N.J. Risch

    Nature

    (2000)
  • R.W. Orrell et al.

    Neurology

    (1997)
  • Cited by (0)

    1

    To whom correspondence should be addressed. Fax: +46-8-343849. E-mail: [email protected].

    View full text