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Antioxidant and Prooxidant Properties of Carotenoids

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Abstract

The ability of dietary carotenoids such as β-carotene and lycopene to act as antioxidants in biological systems is dependent upon a number of factors. While the structure of carotenoids, especially the conjugated double bond system, gives rise to many of the fundamental properties of these molecules, it also affects how these molecules are incorporated into biological membranes. This, in turn, alters the way these molecules interact with reactive oxygen species, so that the in vivo behavior may be quite different from that seen in solution. The effectiveness of carotenoids as antioxidants is also dependent upon their interaction with other coantioxidants, especially vitamins E and C. Carotenoids may, however, lose their effectiveness as antioxidants at high concentrations or at high partial pressures of oxygen. It is unlikely that carotenoids actually act as prooxidants in biological systems; rather they exhibit a tendency to lose their effectiveness as antioxidants.

References (63)

  • W. Stahl et al.

    Arch. Biochem. Biophys.

    (2000)
  • D.C. Liebler et al.

    Methods Enzymol.

    (1992)
  • P. Di Mascio et al.

    Arch. Biochem. Biophys.

    (1989)
  • P.F. Conn et al.

    J. Photochem. Photobiol. B.

    (1991)
  • A.A. Woodall et al.

    Biochim. Biophys. Acta

    (1997)
  • A.A. Woodall et al.

    Biochim. Biophys. Acta

    (1997)
  • M. Havaux

    Trends Plant Sci.

    (1998)
  • M. Havaux et al.

    J. Photochem. Photobiol. B

    (1991)
  • J.E. Sarry et al.

    FEBS Lett.

    (1994)
  • M. van de Ven et al.

    Biophys. J.

    (1984)
  • L.B.-A. Johansson et al.

    FEBS Lett.

    (1981)
  • W.K. Subczynski et al.

    Biochim. Biophys. Acta

    (1991)
  • S.Q. Alam et al.

    J. Nutr.

    (1983)
  • P. Palozza et al.

    Free Radical Biol. Med.

    (1995)
  • M.G. Salgo et al.

    Free Radical Biol. Med.

    (1999)
  • P. Palozza et al.

    Arch. Biochem. Biophys.

    (1996)
  • J.A. Woods et al.

    FEBS Lett.

    (1999)
  • A.V. Ruban et al.

    J. Photobiol. Photobiochem. B.

    (1993)
  • T.G. Truscott

    J. Photochem. Photobiol. B.

    (1996)
  • F. Böhm et al.

    FEBS Lett.

    (1998)
  • W. Stahl et al.

    FEBS Lett.

    (1998)
  • P. Palozza et al.

    Arch. Biochem. Biophys.

    (1992)
  • Halliwell, B, and, Gutteridge, J. M. C. 1999, Free Radicals in Biology and Medicine, 3rd ed, Oxford Univ. Press,...
  • R.G. Ziegler et al.

    Cancer Causes Control

    (1996)
  • R. Peto et al.

    Nature

    (1981)
  • G.S. Omenn et al.

    N. Engl. J. Med.

    (1996)
  • Beta Carotene Cancer Prevention Study Group The Alpha-Tocopherol

    N. Engl. J. Med.

    (1994)
  • D. Albanes et al.

    J. Natl. Cancer Inst.

    (1996)
  • S.T. Mayne et al.

    J. Natl. Cancer Inst.

    (1996)
  • S.T. Mayne

    FASEB J.

    (1996)
  • X-D. Wang et al.

    Nutr. Rev.

    (1999)
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