n=5197 | |
Maternal characteristics | |
Education, higher (%) | 51.6 (2685) |
Body mass index at intake (kg/m2) | 24.6 (4.25) |
Parity, nullipara (%) | 56.6 (2942) |
Smoking during pregnancy, yes (%) | 14.0 (729) |
Psychiatric symptoms during pregnancy (GSI)* | 0.17 (0.06, 0.38) |
Pet keeping, yes (%) | 38.1 (1982) |
History of asthma or atopy, yes (%) | 37.2 (1936) |
Mode of delivery, caesarian section (%) | 13.6 (709) |
Children’s characteristics | |
Female sex (%) | 50.5 (2,626) |
Gestational age at birth (weeks)* | 40.0 (39.1, 41.0) |
Preterm birth <37 weeks (%) | 4.3 (223) |
Birth weight (g) | 3444 (550) |
Breastfeeding never (%) | 8.1 (419) |
Day care attendance 1st year, yes (%) | 58.2 (3025) |
Environmental tobacco smoke exposure first 2 years, yes (%) | 19.3 (1005) |
Use of antibiotics 1st year, yes (%) | 63.0 (3278) |
Use of paracetamol 1st year, yes (%) | 87.8 (4569) |
Inhalant allergic sensitisation at age 10 years, yes (%) | 31.8 (1.172) |
FEV1 (L) | 2.02 (0.30) |
FEV1 (Z-score) | 0.17 (0.97) |
FVC (L) | 2.33 (0.36) |
FVC (Z-score) | 0.21 (0.93) |
FEV:FEV (%) | 86.6 (5.7) |
FEV1:FVC (Z-score) | −0.11 (0.95) |
FEF75 (L/s) | 1.14 (0.35) |
FEF75 (Z-score) | 0.00 (0.91) |
Current asthma, yes (%) | 5.5 (252) |
Early wheezing, yes (%) | 59.5 (1828) |
Late wheezing, yes (%) | 20.0 (690) |
Values are means (SD), valid percentages (absolute numbers) or * medians (25%–75% range) based on imputed data. Data on FVC (available n=4672), FEV1 (n=4672), FEV1:FVC ratio (n=4672), forced expiratory flow when 75% of the FVC is exhaled (FEF75) (n=4672), current asthma (n=4556) and early (n=3074) and late (n=3443) wheezing were not imputed.
GSI, Global Severity Index.