Table 5

Suggested antibiotic regimens for adults with Mycobacterium malmoense-pulmonary disease

M. malmoense-pulmonary diseaseAntibiotic regimen
Non-severe M. malmoense-pulmonary disease
(ie, AFB smear-negative respiratory tract samples, no radiological evidence of lung cavitation or severe infection, mild-moderate symptoms, no signs of systemic illness)
Rifampicin 600 mg daily and Ethambutol 15 mg/kg daily and Azithromycin 250 mg daily or clarithromycin 500 mg twice daily
Antibiotic treatment should continue for a minimum of 12 months after culture conversion.
Severe M. malmoense-pulmonary disease
(ie, AFB smear-positive respiratory tract samples, radiological evidence of lung cavitation/severe infection or severe symptoms/signs of systemic illness)
Rifampicin 600 mg daily and Ethambutol 15 mg/kg daily and Azithromycin 250 mg daily or clarithromycin 500 mg twice daily and consider intravenous amikacin for up to 3 months or nebulised amikacin
Antibiotic treatment should continue for a minimum of 12 months after culture conversion.
  • AFB, acid-fast bacilli.