Differences between exercise and control groups following the intervention
| 9 week follow-up | 6 month follow-up | p Value | |||
|---|---|---|---|---|---|
| Mean difference (95% CI) | Group | Time | Group×time | ||
| 6MWD (m) | 25 (2 to 47) | 21 (−3 to 44) | 0.03 | <0.001 | 0.7 |
| Knee extensor strength (kg) | 1.3 (−0.1 to 2.6) | 0.8 (−0.7 to 2.2) | 0.1 | 0.5 | 0.5 |
| Elbow flexor strength (kg) | 0.3 (−0.7 to 1.3) | −0.2 (−1.2 to 0.8) | 0.9 | 0.003 | 0.4 |
| CRDQ Dyspnoea | 2.5 (0.6 to 4.3) | 1.2 (−0.7 to 3.1) | 0.02 | 0.7 | 0.2 |
| CRDQ Fatigue | 2.6 (1.1 to 4.1) | 1.4 (−0.3 to 2.9) | 0.003 | 0.1 | 0.1 |
| CRDQ Emotional function | 3.3 (1.0 to 5.6) | 2.0 (−0.3 to 4.4) | 0.008 | 0.2 | 0.3 |
| CRDQ Mastery | 3.3 (1.4 to 5.2) | 0.4 (−1.5 to 2.3) | 0.02 | 0.004 | 0.01 |
| SGRQ-I Symptoms | −9.0 (−15.4 to −2.5) | −9.0 (−15.5 to −2.2) | 0.001 | 1.0 | 1.0 |
| SGRQ-I Activity | −5.9 (−11.2 to −0.4) | −4.0 (−9.5 to 1.5) | 0.04 | 0.8 | 0.5 |
| SGRQ-I Impact | −6.4 (−11.4 to −1.4) | 0.6 (−4.5 to 5.7) | 0.2 | 0.9 | 0.006 |
| SGRQ-I Total | −5.8 (−9.7 to −1.9) | −1.4 (−5.4 to 2.7) | 0.04 | 1.0 | 0.04 |
| UCSD SOBQ | 3.2 (−2.7 to 9.1) | −0.007 (−6.0 to 6.0) | 0.6 | 0.01 | 0.2 |
| MMRC dyspnoea scale | −0.3 (−0.5 to 0.04) | −0.2 (−0.5 to 0.05) | 0.06 | 0.6 | 1.0 |
Data are estimated marginal means, exercise group – control group derived from linear mixed models. p Values are for group effect (between-group difference independent of time), time effect (change over time independent of group) and group×time interaction. p Values <0.05 were considered statistically significant.
Positive increase represents improvement except for MMRC, UCSD SOBQ and SGRQ-I.
6MWD, six-minute walk distance; CRDQ, Chronic Respiratory Disease Questionnaire; IPF, idiopathic pulmonary fibrosis; MMRC, Modified Medical Research Council; SGRQ-I, St George Respiratory Questionnaire IPF-specific version; UCSD SOBQ, University College of San Diego Shortness of Breath Questionnaire.