Table 6
Associations with evaluated child contacts (of index cases with TB at any site) being diagnosed with LTBI
| Characteristic of the index case | Child contact diagnosed with LTBI | |||
|---|---|---|---|---|
| Yes (row %)* | No* | aOR (95% CI) | p Value | |
| Total | 440 (10%) | 3865 | N/a | N/a |
| UK born | ||||
| Yes | 113 (16%) | 611 | 1.23 (0.85 to 1.78) | 0.44 |
| No, long-term migrant | 285 (9%) | 2854 | 1 | |
| No, recent migrant | 42 (10%) | 400 | 0.87 (0.51 to 1.48) | |
| History of drug use | ||||
| Yes | 29 (18%) | 136 | 1.35 (0.62 to 2.96) | 0.45 |
| No | 411 (10%) | 3729 | 1 | |
| History of homelessness | ||||
| Yes | 17 (14%) | 108 | 0.95 (0.47 to 1.94) | 0.90 |
| No | 423 (10%) | 3757 | 1 | |
| Former prisoner | ||||
| Yes | 8 (10%) | 74 | 0.53 (0.21 to 1.36) | 0.19 |
| No | 432 (10%) | 3791 | 1 | |
| Sex | ||||
| Male | 218 (10%) | 1995 | 0.80 (0.59 to 1.09) | 0.16 |
| Female | 222 (11%) | 1870 | 1 | |
| Ethnicity | ||||
| Indian | 62 (8%) | 700 | 1 | 0.41 |
| Black African | 134 (10%) | 1232 | 1.07 (0.69 to 1.64) | |
| White | 72 (18%) | 322 | 1.54 (0.90 to 2.62) | |
| Other | 172 (10%) | 1611 | 1.06 (0.71. 1.58) | |
| Culture | ||||
| Positive | 375 (14%) | 2283 | 1 | <0.01 |
| Negative | 49 (4%) | 1260 | 0.51 (0.34 to 0.76) | |
| Not done | 16 (5%) | 322 | 0.60 (0.33 to 1.11) | |
| Disease type | ||||
| Non-pulmonary and non-laryngeal | 67 (3%) | 2041 | 1 | <0.01 |
| Pulmonary smear-negative | 91 (10%) | 823 | 2.92 (1.96 to 4.35) | |
| Pulmonary smear-positive | 252 (27%) | 692 | 8.39 (5.76 to 12.2) | |
| Pulmonary, smear unknown or laryngeal | 30 (9%) | 309 | 2.35 (1.35 to 4.10) | |
| BCG | ||||
| Not vaccinated | 87 (10%) | 822 | 0.83 (0.56 to 1.21) | 0.54 |
| Vaccinated | 280 (11%) | 2343 | 1 | |
| Unknown | 73 (9%) | 700 | 1.08 (0.72 to 1.60) | |
| Clinic case count* (linear, 100 cases/year) |  | s=0.52 | 1.22 (0.85 to 1.76) | 0.28 |
| Age of index case | ||||
| 0–14 years | 30 (18%) | 134 | 1 | 0.01 |
| 15 years and over | 410 (10%) | 3731 | 0.40 (0.20 to 0.77) | |
| Notification rate*† (linear, 10 cases/100 000 population/year) |  | s=1.8 | 1.04 (0.93 to 1.16) | 0.45 |
| Contact screened at clinic | ||||
| Yes | 388 (11%) | 3306 | 1.29 (0.83 to 2.01) | 0.27 |
| No | 52 (8.5%) | 559 | 1 | |
*Mean and SD presented for continuous variables.
†Notification rate in the year and local authority in which the index case was notified. N=4305.
aOR, adjusted OR; LTBI, latent TB infection.