Abstract P59 Table 1

Variable	Multivariate Cox Regression Analysis
Variable	HR	95% CI	P-value
Composite: exacerbations^a	2.380	2.170, 2.611	<0.0001
Elective secondary care contact	1.445	1.305, 1.601	<0.0001
Markers of COPD proactive planned care within primary care setting	1.268	1.231, 1.305	<0.0001
Reactive COPD care within primary care setting	1.155	1.115, 1.198	<0.0001
Composite: cardiovascular^b	1.150	1.025, 1.291	0.0175
Number of cough symptoms	1.086	1.046, 1.128	<0.0001
Number of short-acting bronchodilator prescriptions	1.033	1.027, 1.038	<0.0001
Age at index date^c	0.992	0.988, 0.995	<0.0001
Sex (female)	0.798	0.735, 0.867	<0.0001
Diabetes	0.685	0.530, 0.886	0.0039

AECOPD, acute exacerbation of COPD; CI, confidence interval; HR, hazard ratio.
^aExacerbations (COPD emergency admission or AECOPD or lower respiratory tract infection or oral corticosteroid + antibiotic)
^bCombined comorbidity for cardiovascular risk (heart failure, congestive heart disease, hypertensive disease, cerebrovascular disease, atrial fibrillation)
^cHR relative to change to every 1 year difference in age.