Study population and changes in metabolite groups in venous blood of patients compared to healthy controls
| Chronic pulmonary vascular occlusions (n = 43) | Controls (n = 27) | |
|---|---|---|
| Group demographics | ||
| Age (years) | 58 (22–77) | 44 (18–75) |
| Sex (% male) | 64 | 60 |
| Patient group | ||
| Proximal CTEPH- treatment naive (n) | 11 | |
| Distal CTEPH (n) | 3 | |
| Proximal CTEPH- previous pulmonary endarterectomy- residual PH (n) | 11 | |
| Proximal CTEPH- previous pulmonary endarterectomy, no residual PH (n) | 10 | |
| Chronic thromboembolic vascular occlusions without PH (n) | 8 | |
| Changes in metabolites in disease | ||
| Acylcarnitines | ↑ | |
| Long chain fatty acids | ↑ | |
| Polyamines | ↑ | |
| Glycogen metabolites | ↑ | |
| Primary bile acid metabolites | ↑ | |
| Lysolipids | ↓ | |
| Plasmalogens | ↓ | |
| Aminosugars | ↓ | |
| Branched chain amino acids | ↓ | |
| Glutathione metabolites | ↓ | |
| Steroids | ↓ | |