Abstract M12 Table 1

TRPV1 single nucleotide polymorphism, cough reflex sensitivity and cough frequency in chronic cough

TRPV1 SNPnC5 (µM/L)regn coeff.
(95% CI) 		p CF24regn coeff. (95% CI) P
rs161365
CC
CT
TT 		29
18
7		10.4 (5.0–19.1)
6.9 (2.5–12.0)
3.9 (1.4–16.6)		−0.38
(−1.07 to 0.31)		0.277499 (260–840)
458 (111–636)
251 (147–362)		−0.24
(−0.68 to 0.19)		0.263
rs17706630
GG
GA
AA 		37
16
1		7.8 (4.9–15.6)
5.7 (1.3–15.6)
15.6 (n/a)		−0.34
(−1.31 to 0.63)		0.487436 (197–636)
362 (120–976)
154 (n/a)		0.02
(−0.59 to 0.63)		0.943
rs2277675
TT
TC
CC 		26
25
3		9.41 (5.3–15.6)
5.9 (1.9–13.8)
22.1 (3.9–49.6)		0.10
(−0.68 to 0.89)		0.795499 (205–635)
362 (154–1187)
104 (42–285)		−0.25
(−0.74 to 0.25)		0.321
rs222741
AA
AG
GG 		28
18
7		7.8 (3.9–15.6)
5.4 (2.5–23.0)
12.0 (7.8–16.6)		0.38
(−0.31 to 1.08)		0.274338 (111–636)
425 (292–738)
567 (212–611)		−0.14
(−0.31 to 0.59)		0.534
rs150854
TT
TG
GG 		19
28
4		11.0 (5.5–16.6)
6.1 (3.4–17.1)
9.8 (6.0–11.0)		−0.29
(−1.18 to 0.61)		0.525458 (147–611)
399 (166–1081)
448 (241–949)		0.32
(−0.22 to 0.85)		0.237
rs224498
TT
TG
GG 		26
22
6		9.8 (5.1–19.7)
7.8 (3.4–15.6)
6.7 (0.5–11.0)		−0.47
(−1.19 to 0.25)		0.198410 (209–636)
380 (120–634)
695 (441–1985)		0.10
(−0.38 to 0.57)		0.684

  • SNP – single nucleotide polymorphism, C5 – minimum capsaicin concentration required to produce 5 coughs, CF24 – 24-hour cough frequency. Values of C5 and CF24 are median (IQR). Regression coefficients are per minor allele effects from linear regression analyses with associated p – values.