Lung function tests comparing extremely preterm and control children
| Differences from control | |||||
|---|---|---|---|---|---|
| Mod/sev BPD (mean±SD) | No/mild BPD (mean±SD) | Control (mean±SD) | Mod/sev BPD (mean (95% CI)) | No/mild BPD (mean (95% CI)) | |
| zFEV1‡ | −0.92±1.36 | −0.50±1.10 | 0.09±1.01 | −1.00 (−1.54 to −0.47)† | −0.58 (−1.10 to −0.068)* |
| zFVC | −0.85±1.67 | 0.35±1.25 | 0.47±0.90 | ||
| zFEV1/FVC† | −1.14±1.5 | −1.3±0.80 | −0.57±1.14 | −0.56 (−1.11 to −0.015)† | −0.71 (−1.25 to −0.19)† |
| zFEF25–75‡ | −1.6±1.22 | −1.3±0.87 | −0.48±1.12 | −1.09 (−1.59 to −0.58)‡ | −0.84 (−1.33 to −0.35)‡ |
| zTLC | 0.63±1.08 | 0.66±1.10 | 0.38±1.02 | ||
| zRV* | 0.092±1.12 | −0.16±0.95 | −0.47±0.97 | 0.56 (0.70 to 1.06)* | |
| zRV/TLC† | −0.19±1.33 | −0.55±1.04 | −0.91±1.00 | 0.72 (0.18 to 1.27)† | |
| zFRC | 0.22±1.12 | 0.072±0.92 | −0.29±1.11 | ||
| zTLCO | −0.49±0.76 | −0.52±0.82 | −0.32±0.69 | ||
| zTLCO/VA† | −1.64±0.89 | −1.57±0.76 | −1.06±0.95 | −0.58 (−1.02 to −0.13)† | −0.50 (−0.91 to −0.10)† |
| MVV (L) | 79.5±27.5 | 83.3±27.9 | 93.1±30.7 | ||
*p<0.05; †p<0.01; ‡p<0.001.
BPD, bronchopulmonary dysplasia; FEF25–75, forced expiratory flow between 25–75% of FVC; FRC, functional residual capacity; mod/sev, moderate/severe; MVV, maximum voluntary ventilation; RV, residual volume; TLC, total lung capacity; TLCO, transfer factor for carbon monoxide; VA, alveolar volume; z, z-score.