Univariable and multivariable analyses of trial allocation effects on cancer distress over T1 and T2
| Cancer distress effect modifiers | Logn difference in cancer distress | |
|---|---|---|
| Estimate (unadjusted), 95% CI, p value | Estimate (adjusted)*, 95% CI, p value | |
| Trial allocation (Intervention–Control) | 0.02 (−0.13 to 0.17) 0.42 | 0.03 (−0.20 to 0.26) 0.39 |
| Gender (Female–Male) | 0.04 (0.03 to 0.06) ≤0.001 | 0.02 (0.01 to 0.04) ≤0.01 |
| Age group | ||
| Up to 65–over 70 | 0.06 (0.05 to 0.08) ≤0.001 | 0.05 (0.03 to 0.07) ≤0.001 |
| 66 to 70–over 70 | 0.04 (0.02 to 0.05) ≤0.001 | 0.02 (0.02 to 0.04) 0.02 |
| Smoking | ||
| Ex-smoker–Current smoker | −0.08 (−0.06 to −0.09) ≤0.001 | −0.06 (−0.05 to −0.08) ≤0.001 |
| Never smoker†–Current smoker | † | † |
| IMD | ||
| Q1 (most deprived)–Q5 (least deprived) | 0.09 (0.07 to 0.10) ≤0.001 | 0.02 (−0.01 to 0.04) 0.13 |
| Q2–Q5 | 0.05 (0.03 to 0.07) ≤0.001 | 0.01 (−0.02 to 0.03) 0.66 |
| Q3–Q5 | 0.03 (0.01 to 0.04) ≤0.01 | −0.00 (−0.02 to 0.02) 0.89 |
| Q4–Q5 | 0.02 (0.00 to 0.04) 0.029 | 0.01 (−0.01 to 0.03) 0.59 |
| Education (Up to GCSE/O level–beyond GCSE/O level) | 0.01 (0.00 to 0.03) 0.05 | – |
| Ethnicity (White–non-white) | 0.01 (−0.06 to 0.08) 0.79 | – |
| Marital group | ||
| Married–Single | −0.04 (−0.02 to –0.07) ≤0.001 | – |
| Married–Cohabiting | 0.01 (−0.02 to 0.04) 0.41 | – |
| Married–Widowed | −0.03 (−0.00 to –0.05) 0.03 | – |
| Married–Divorced | −0.05 (−0.03 to –0.07) ≤0.001 | – |
| Experience of lung cancer (Yes–No) | 0.05 (0.03 to 0.06) ≤0.001 | 0.03 (0.02 to 0.05) ≤0.001 |
| Site (Liverpool–Cambridge) | 0.07 (0.06 to 0.08) ≤0.001 | 0.06 (0.04 to 0.07) ≤0.001 |
| Time since attended recruitment centre | ||
| 3 to 6 months–<3 months | −0.00 (−0.03 to 0.03) 1.00 | −0.03 (0.00 to −0.05) 0.09 |
| 6 to 12 months–<3 months | −0.05 (−0.09 to −0.01) 0.03 | −0.06 (−0.11 to −0.01) 0.03 |
| >12 months–<3 months | −0.03 (−0.12 to 0.06) 0.09 | −0.05 (−0.00 to −0.10) 0.05 |
| Screening result | ||
| Positive (repeat scan)–Negative | 0.09 (0.07 to 0.11) ≤0.001 | – |
| Positive (referral)–Negative | 0.20 (0.15 to 0.24) ≤0.001 | – |
| Incidental–Negative | 0.02 (−0.02 to 0.07) 0.33 | – |
Data are presented for participants with low T0 cancer distress (n=2896/3225, 90%). Base model adjustment factors included: T0 cancer distress, trial allocation, gender, age, smoking, deprivation, education, ethnicity, marital group, time since recruitment, recruitment site and experience of lung cancer.
*Adjusted for T0 cancer distress, trial allocation, gender, age, smoking, deprivation, time since recruitment, recruitment site and experience of lung cancer.
†Data were excluded due to limited variation.
GCSE, General Certificate of Secondary Education; IMD, Index of Multiple Deprivation.