5 mm (with 95% CIs) | 10 mm (with 95% CIs) | 15 mm (with 95% CIs) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Age (years) | Sensitivity | Specificity | PPV | NPV | Sensitivity | Specificity | PPV | NPV | Sensitivity | Specificity | PPV | NPV |
All children | 100 (90.3 to 100) | 90.7 (82.5 to 95.9) | 81.8 (67.3 to 91.8) | 100 (95.4 to 100) | 97.2 (85.5 to 99.9) | 91.9 (84.0 to 96.7) | 83.3 (68.6 to 93.0) | 98.8 (93.2 to 100) | 86.1 (70.5 to 95.3) | 94.2 (87.0 to 98.1) | 86.1 (70.5 to 95.3) | 94.2 (87.0 to 98.1) |
0 to <2 | 100 (2.5 to 100) | 94.7 (74.0 to 99.9) | 50.0 (1.3 to 98.7) | 100 (81.5 to 100) | 100 (2.5 to 100) | 94.7 (74.0 to 99.9) | 50.0 (1.3 to 98.7) | 100 (81.5 to 100) | 100 (2.5 to 100) | 100 (82.4 to 100) | 100 (2.5 to 100) | 100 (82.4 to 100) |
2 to <5 | 100 (59.0 to 100) | 96.0 (79.7 to 99.0) | 87.5 (47.4 to 99.7) | 100 (85.8 to 100) | 85.7 (42.1 to 99.6) | 96.0 (79.7 to 99.9) | 85.7 (42.1 to 99.6) | 96.0 (79.7 to 99.9) | 71.4 (29.0 to 96.3) | 96.0 (79.7 to 99.9) | 83.3 (35.9 to 99.6) | 92.3 (74.9 to 99.0) |
5 to <10 | 100 (76.8 to 100) | 85.2 (66.3 to 95.8) | 77.8 (52.4 to 93.6) | 100 (85.2 to 100) | 100 (76.8 to 100) | 88.9 (70.8 to 97.7) | 82.4 (56.6 to 96.2) | 100 (85.8 to 100) | 85.7 (57.2 to 98.2) | 92.6 (75.7 to 99.1) | 85.7 (57.2 to 98.2) | 92.6 (75.7 to 99.1) |
10 to <15 | 100 (76.8 to 100) | 86.7 (59.5 to 98.3) | 87.5 (61.7 to 98.5) | 100 (75.3 to 100) | 100 (76.8 to 100) | 86.7 (59.5 to 98.3) | 87.5 (61.7 to 98.5) | 100 (75.3 to 100) | 92.9 (66.1 to 99.8) | 86.7 (59.5 to 98.3) | 86.7 (59.5 to 98.3) | 92.9 (66.1 to 99.8) |
IGRA, interferon γ release assay; NPV, negative predictive value; PPV, positive predictive value; TST, tuberculin skin test.