Table 1

Baseline characteristics

Characteristic*Metformin group (n=34)Placebo group (n=18)p Value
Age, year69±1065±80.258
Sex, M/F21/1311/70.963
Body mass index, kg/m226.0±5.925.6±6.10.834
Past medical history, n (%)
 Myocardial infarction6 (18%)1 (6%)0.399
 Heart failure3 (9%)1 (6%)>0.99
 Atrial fibrillation4 (12%)2 (11%)>0.99
 Cerebrovascular disease3 (9%)0 (0%)0.543
Charlson comorbidity index0.5 (0–1)0.0 (0–1)0.424
Smoking history, pack-years54±5254±210.961
Pulse, bpm93±1392±120.769
Systolic blood pressure, mm Hg133±21137±230.544
Diastolic blood pressure, mm Hg75±1080±130.133
Respiratory rate, breaths/min19±219±30.705
Arterial blood gases
 pH7.42±0.057.41±0.050.854
pCO2, kPa5.5±1.25.6±1.10.649
pO2, kPa9.2±2.59.4±2.20.824
Biochemistry
 Urea, mmol/L5.7±1.75.4±2.30.693
 Creatinine, μmol/L73±1772±230.861
 Haemoglobin A1c, mmol/mol42 (40–44)42 (39–44)0.821
 C reactive protein, mg/L14 (5–77)17 (5–59)0.840
Radiographic consolidation, n (%)7 (21%)3 (17%)0.827
  • *Continuous data are presented as mean±SD or median (IQR), as applicable.