Table 1

Cystic fibrosis biomarkers studied with approved cystic fibrosis transmembrane conductance regulator (CFTR) modulators

Biomarker	Ivacaftor in G551D	Lumacaftor–ivacaftor in F508del/F508del	References
Sweat chloride	√	√	16^, 22^, 26^, 28–31
Nasal potential difference	√	√	22^, 26^, 28
Mucociliary clearance	√		22
Duodenal pH	√		22
Sputum inflammatory markers*	√		22
Lung clearance index	√		32
Exhaled NO	√		33
Sweat rate	√		22