Associations of FEV1 and FVC (expressed as % of predicted values) with log-transformed N-terminal pro-brain natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) in men with no prior heart failure or myocardial infarction
| FEV1 | p Value | FVC β coefficients (95% CI) | p Value | |
|---|---|---|---|---|
| Log NT-proBNP (pg/mL) | Change in log NT-pro BNP per increase in 10 percentile change in FEV1 | Change in log NT-pro BNP per increase in 10 percentile change in FVC | ||
| Age-adjusted | −0.054 (−0.070 to −0.038) | <0.001 | −0.053 (−0.071 to −0.035) | <0.001 |
| Model 1 | −0.034 (−0.050 to −0.018) | <0.001 | −0.029 (−0.048 to −0.011) | <0.001 |
| Model 2 | −0.023 (−0.039 to −0.007) | 0.005 | −0.021 (−0.037 to −0.003) | 0.026 |
| Model 3 | −0.024 (−0.048 to 0.000) | 0.050 | 0.00008 (−0.028 to 0.029) | 0.950 |
| Log cTnT (pg/mL) | Change in log cTnT increase in 10 percentile change in FEV1 | Change in log CTnT per increase in 10 percentile change in FVC | ||
| Age−adjusted | −0.024 (−0.032 to −0.016) | <0.001 | −0.033 (−0.041 to −0.025) | <0.001 |
| Model 1 | −0.024 (−0.032 to −0.016) | <0.001 | −0.030 (−0.038 to −0.022) | <0.001 |
| Model 2 | −0.021 (−0.029 to −0.013) | <0.001 | −0.027 (−0.035 to −0.019) | <0.001 |
| Model 3 | −0.004 (−0.014 to 0.006) | 0.450 | −0.024 (−0.036 to −0.012) | 0.002 |
Model 1=adjusted for age, smoking status, physical activity, heavy drinking, social class, body mass index, left ventricular hypertrophy, systolic blood pressure, use of antihypertensive drugs, diabetes, stroke and atrial fibrillation.
Model 2=model 1+ C-reactive protein (CRP).
Model 3=Model 1+CRP+FEV and FVC.