List of proteins with differential abundance in the plasma of subjects with versus without an imminent pulmonary exacerbation
| MRM-MS protein | Fold difference* | Direction of difference* | p Value |
|---|---|---|---|
| CRP† | 2.63 | Up | 0.03 |
| Peroxiredoxin-2† | 2.02 | Down | 0.70 |
| Haemoglobin subunit alpha**† | 1.91 | Down | 0.39 |
| Carbonic anhydrase 1† | 1.67 | Down | 0.06 |
| CD5† | 1.63 | Down | 0.17 |
| Apolipoprotein C-II† | 1.59 | Down | 0.03 |
| Protease C1 inhibitor | 1.30 | Down | <0.01 |
| Insulin-like growth factor binding protein | 1.26 | Down | <0.01 |
| Transthyretin | 1.25 | Down | 0.01 |
| Fibrinogen | 1.23 | Up | 0.01 |
| Serine protease inhibitor | 1.22 | Down | <0.01 |
| Albumin | 1.21 | Down | <0.01 |
*Plasma levels of candidate protein among individuals with an imminent pulmonary exacerbation (<4 months) relative to levels among individuals without an imminent pulmonary exacerbation.
†Included in final MRM-MS panel.
CRP, C-reactive protein; MRM-MS, multiple reaction monitoring mass spectrometry.