Comparison of candidate plasma protein levels in subjects with versus without an imminent pulmonary exacerbation
| Candidate protein* | Fold difference† | Direction of difference† | p Value |
|---|---|---|---|
| CRP | 2.63 | Up | 0.03 |
| IL-6 | 1.67 | Up | 0.02 |
| NEAPC | 1.26 | Up | 0.92 |
| MPO | 1.25 | Up | 0.92 |
| sCD14 | 1.01 | Up | 0.76 |
*Measured with ELISA except CRP, which was measured with multiple reaction monitoring mass spectrometry.
†Plasma levels of candidate protein among individuals with an imminent pulmonary exacerbation (<4 months) relative to levels among individuals without an imminent pulmonary exacerbation.
CRP, C-reactive protein; IL-6, interleukin-6, MPO, myeloperoxidase; NEAPC, neutrophil elastase antiproteinase complex; sCD14, soluble CD14.