Table 1

Total lung cytokine levels (pg/mL) in septic wild-type (WT) and interleukin (IL)-27R–/– mice after secondary challenge with Pseudomonas aeruginosa

	0	4 h	24 h
TNF-α
WT	188±56	333±85	521±76
IL-27R−/−	211±87	581±161*	663±131
IL-1β
WT	133±59	253±81	356±113
IL-27R−/−	226±88	468±116*	612±176
CXCL1
WT	372±112	551±162	761±176
IL-27R−/−	486±98	887±152*	826±168
CXCL2
WT	121±57	281±76	316±103
IL-27R−/−	176±85	423±100*	488±176
CXCL10
WT	622±137	1008±515	1536±656
IL-27R−/−	867±226	1883±917*	2127±1168*
IL-6
WT	512±167	778±333	1179±613
IL-27R−/−	692±328	1097±512*	1088±675
IL-12
WT	311±112	453±184	583±222
IL-27R−/−	466±176	727±226*	813±336
IL-17
WT	115±55	279±165	421±126
IL-27R−/−	176±73	511±183*	633±262
IL-10
WT	1768±843	3611±1347	4611±1356
IL-27R−/−	1255±933	2151±1687	2873±1634*

Data were expressed as mean±SEM. Differences between WT and IL-27R−/− mice were analysed using the non-parametric Mann–Whitney test.
*p<0.05 compared with corresponding WT control. n=6 mice per time point.
TNF-α, tumour necrosis factor α.