Subject characteristics and pulmonary function
| Healthy (n=11) | Mild–mod COPD (n=8) | Severe COPD (n=11) | |
|---|---|---|---|
| Age (years) | 60 (1) | 61 (2) | 60 (3) |
| Sex (M:F) | 6:5 | 3:5 | 6:5 |
| Height (cm) | 172 (3) | 166 (3) | 168 (3) |
| Weight (kg) | 75 (5) | 84 (6) | 69 (3) |
| BMI (kg/m2) | 25 (1) | 30± (2) | 24 (1)† |
| CAT (of/40) | 4 (0–9) | 12 (4–24)* | 21 (11–31)**† |
| Pulmonary function | |||
| FEV1 (L) | 3.1 (0.3) | 1.9 (0.2)* | 0.9 (0.1)**† |
| FEV1 (%pred) | 104 (5) | 72 (3)** | 32 (2)**†† |
| FVC (L) | 4.2 (0.3) | 3.1 (0.4) | 2.7 (0.2)* |
| FVC (%pred) | 114 (4) | 96 (4)* | 79 (5)** |
| FEV1/FVC | 74 (2) | 62 (3)* | 32 (2)**†† |
| TLC (L) | 6.9 (0.5) | 6.7 (0.8) | 7.8 (0.3) |
| TLC (%pred) | 110 (3) | 113 (5) | 138 (3)**† |
| RV (L) | 2.4 (0.2) | 3.0 (0.3) | 4.4 (0.3)**† |
| RV (%pred) | 109 (5) | 137 (13) | 203 (7.5)**†† |
| RV/TLC (%) | 35 (2) | 46 (4) | 56 (3)** |
| TLCOc (%pred) | 98 (6) | 74 (5)* | 43 (4)**† |
Data shown as mean (SEM) or median (range). *p<0.05, **p<0.01 from healthy, †p<0.05, ††p<0.01 from mild–mod COPD. Note, lung volume and gas transfer data available in 21 subjects.
BMI, body mass index; CAT, COPD assessment tool; RV, residual volume; TLC, total lung capacity; TLCOc, transfer coefficient for carbon monoxide corrected for haemoglobin.