Effect of presence or absence of surgery on associations of hospital of treatment and distance from a NASH with hazard of death from NSCLC in patients with localised, regional and distant stage disease
| Hospital of treatment and distance from a NASH | HR | 95% CI | p Value | HR | 95% CI | p Value |
|---|---|---|---|---|---|---|
| Multivariable model including surgery* | Multivariable model excluding surgery* | |||||
| Localised NSCLC patients (n=3240) | ||||||
| Specialist hospital 0–39.9 | 1 | 1 | ||||
| Specialist hospital 40–99.9 | 0.82 | (0.64 to 1.05) | 1.32 | (0.96 to 1.82) | ||
| Specialist hospital 100+ | 0.64 | (0.51 to 0.81) | 0.96 | (0.72 to 1.28) | ||
| General hospital 0–39.9 | 1.69 | (1.43 to 2.00) | 1.28 | (1.00 to 1.65) | ||
| General hospital 40–99.9 | 2.01 | (1.63 to 2.48) | 1.57 | (1.14 to 2.18) | ||
| General hospital 100+ | 1.82 | (1.55 to 2.13) | p<0.0001 | 1.02 | (0.80 to 1.29) | p<0.022 |
| Regional NSCLC patients(n=2435) | ||||||
| Specialist hospital 0–39.9 | 1 | 1 | ||||
| Specialist hospital 40–99.9 | 0.82 | (0.66 to 1.01) | 0.99 | (0.79 to 1.23) | ||
| Specialist hospital 100+ | 0.77 | (0.63 to 0.93) | 0.93 | (0.76 to 1.13) | ||
| General hospital 0–39.9 | 1.24 | (1.04 to 1.47) | 0.92 | (0.77 to 1.10) | ||
| General hospital 40–99.9 | 1.58 | (1.26 to 1.98) | 1.03 | (0.82 to 1.30) | ||
| General hospital 100+ | 1.23 | (1.04 to 1.45) | p<0.0001 | 0.84 | (0.71 to 0.99) | p=0.2494 |
| Distant NSCLC patients (n=3540) | ||||||
| Specialist hospital 0–39.9 | 1 | 1 | ||||
| Specialist hospital 40–99.9 | 0.82 | (0.64 to 1.06) | 0.92 | (0.71 to 1.18) | ||
| Specialist hospital 100+ | 0.65 | (0.52 to 0.80) | 0.77 | (0.62 to 0.95) | ||
| General hospital 0–39.9 | 1.18 | (1.06 to 1.30) | 1.12 | (1.01 to 1.24) | ||
| General hospital 40–99.9 | 1.21 | (1.07 to 1.38) | 1.09 | (0.96 to 1.24) | ||
| General hospital 100+ | 1.23 | (1.11 to 1.36) | p<0.0001 | 1.10 | (0.99 to 1.22) | p=0.0097 |
*Adjusted for hospital of treatment and distance from a NASH, sex, age at diagnosis, country of birth, comorbidity, COPD, smoking, method of diagnosis, histology, type of admission and time to diagnosis.
NSCLC, non-small cell lung cancer.